Design, synthesis, docking, ADMET profile, and anticancer evaluations of novel thiazolidine‐2, 4‐dione derivatives as VEGFR‐2 inhibitors
K El‐Adl, H Sakr, SSA El‐Hddad… - Archiv der …, 2021 - Wiley Online Library
The anticancer activity of novel thiazolidine‐2, 4‐diones was evaluated against HepG2, HCT‐
116, and MCF‐7 cells. Among the tested cancer cell lines, HCT‐116 was the most sensitive …
116, and MCF‐7 cells. Among the tested cancer cell lines, HCT‐116 was the most sensitive …
Design, synthesis, molecular docking, anticancer evaluations, and in silico pharmacokinetic studies of novel 5‐[(4‐chloro/2, 4‐dichloro) benzylidene] thiazolidine‐2, 4 …
K El‐Adl, AGA El‐Helby, H Sakr, RR Ayyad… - Archiv der …, 2021 - Wiley Online Library
The anticancer activity of novel thiazolidine‐2, 4‐diones was evaluated against HepG2, HCT‐
116, and MCF‐7 cells. MCF‐7 was the most sensitive cell line to the cytotoxicity of the new …
116, and MCF‐7 cells. MCF‐7 was the most sensitive cell line to the cytotoxicity of the new …
5‐(4‐Methoxybenzylidene) thiazolidine‐2, 4‐dione‐derived VEGFR‐2 inhibitors: design, synthesis, molecular docking, and anticancer evaluations
Abstract A novel series of 5‐(4‐methoxybenzylidene) thiazolidine‐2, 4‐dione derivatives, 5a–
g and 7a–f, was designed, synthesized, and evaluated for their anticancer activity against …
g and 7a–f, was designed, synthesized, and evaluated for their anticancer activity against …
Design, synthesis, molecular docking, and anticancer evaluations of 1‐benzylquinazoline‐2,4(1H,3H)‐dione bearing different moieties as VEGFR‐2 inhibitors
K El‐Adl, AGA El‐Helby, H Sakr… - Archiv der …, 2020 - Wiley Online Library
A novel series of 1‐benzylquinazoline‐2, 4 (1H, 3H)‐dione derivatives, 6a, b to 11a–e, was
designed, synthesized, and evaluated for their anticancer activity against HepG2, HCT‐116 …
designed, synthesized, and evaluated for their anticancer activity against HepG2, HCT‐116 …
Pyridine‐derived VEGFR‐2 inhibitors: rational design, synthesis, anticancer evaluations, in silico ADMET profile, and molecular docking
NM Saleh, AAH Abdel‐Rahman, AM Omar… - Archiv der …, 2021 - Wiley Online Library
Abstract Novel pyridine‐derived compounds (5–19) were designed and synthesized, and
their anticancer activities were evaluated against HepG2 and MCF‐7 cells, targeting the …
their anticancer activities were evaluated against HepG2 and MCF‐7 cells, targeting the …
Benzoxazole/benzothiazole‐derived VEGFR‐2 inhibitors: design, synthesis, molecular docking, and anticancer evaluations
AGA El‐Helby, H Sakr, IH Eissa… - Archiv der …, 2019 - Wiley Online Library
A novel series of benzoxazole/benzothiazole derivatives 4a–c–11a–e were designed,
synthesized, and evaluated for anticancer activity against HepG2, HCT‐116, and MCF‐7 …
synthesized, and evaluated for anticancer activity against HepG2, HCT‐116, and MCF‐7 …
Design, synthesis, molecular docking, and anticancer activity of benzoxazole derivatives as VEGFR‐2 inhibitors
AGA El‐Helby, H Sakr, IH Eissa… - Archiv der …, 2019 - Wiley Online Library
Novel series of benzoxazoles 4a‐f‐16 were designed, synthesized, and evaluated for
anticancer activity against HepG2, HCT‐116, and MCF‐7 cells. HCT‐116 was the most …
anticancer activity against HepG2, HCT‐116, and MCF‐7 cells. HCT‐116 was the most …
Design, synthesis, molecular docking and anticancer evaluations of 5-benzylidenethiazolidine-2, 4-dione derivatives targeting VEGFR-2 enzyme
Abstract Novel series of 5-benzylidenethiazolidine-2, 4-dione derivatives 4 ac-8 af were
designed, synthesized and evaluated for anticancer activity against HepG2, HCT-116 and …
designed, synthesized and evaluated for anticancer activity against HepG2, HCT-116 and …
[HTML][HTML] Synthesis, biological evaluation and computer-aided discovery of new thiazolidine-2, 4-dione derivatives as potential antitumor VEGFR-2 inhibitors
In this study, novel VEGFR-2-targeting thiazolidine-2, 4-dione derivatives with potential
anticancer properties were designed and synthesized. The ability of the designed …
anticancer properties were designed and synthesized. The ability of the designed …
Design and synthesis of thiazolidine-2, 4-diones hybrids with 1, 2-dihydroquinolones and 2-oxindoles as potential VEGFR-2 inhibitors: In-vitro anticancer evaluation …
Abstract A thiazolidine-2, 4-dione nucleus was molecularly hybridised with the effective
antitumor moieties; 2-oxo-1, 2-dihydroquinoline and 2-oxoindoline to obtain new hybrids …
antitumor moieties; 2-oxo-1, 2-dihydroquinoline and 2-oxoindoline to obtain new hybrids …
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