Scavenger receptors were originally defined by their ability to bind and internalize modified
lipoproteins. Macrophages express at least six structurally different cell surface receptors for …

Accumulating evidence indicates that atherosclerosis is a chronic inflammatory disease. The
key innate immune cells that are involved in the pathogenesis of atherosclerosis are …

It is now thirty years since the original observation that macrophages take up and degrade
modified forms of low density lipoprotein (LDL). Molecular cloning has identified multiple …

Macrophages are able to recognise and internalise apoptotic and foreign cells from the
tissue microenvironment and, where pertinent, initiate inflammation and macrophage …

Atherosclerotic vascular disease arises as a consequence of the deposition and retention of
serum lipoproteins in the artery wall. Macrophages in lesions have been shown to express≥ …

Akey aspect of the innate immune system is the ability to discriminate between self and
infectious nonself. This is achieved through pattern recognition receptors which directly …

In atherogenesis, elevated plasma levels of low density lipoprotein (LDL) lead to the chronic
presence of LDL in the arterial wall. There, LDL is modified (eg, oxidized), and these …

Scavenger receptors were originally identified by their ability to recognize and to remove
modified lipoproteins; however, it is now appreciated that they carry out a striking range of …

Scavenger receptors (SR) are expressed by myeloid cells (macrophages and dendritic cells)
and certain endothelial cells. They play an important role in uptake and clearance of effete …

Scavenger receptors are a highly diverse superfamily of proteins which are grouped by their
inherent ability to bind and internalize a wide array of structurally diverse ligands which can …