Antibiotic discovery and resistance: the chase and the race
The history of antimicrobial resistance (AMR) evolution and the diversity of the
environmental resistome indicate that AMR is an ancient natural phenomenon. Acquired …
environmental resistome indicate that AMR is an ancient natural phenomenon. Acquired …
The antibiotic resistome: the nexus of chemical and genetic diversity
GD Wright - Nature reviews microbiology, 2007 - nature.com
Over the millennia, microorganisms have evolved evasion strategies to overcome a myriad
of chemical and environmental challenges, including antimicrobial drugs. Even before the …
of chemical and environmental challenges, including antimicrobial drugs. Even before the …
Antibiotic resistance: it's bad, but why isn't it worse?
N Waglechner, GD Wright - BMC biology, 2017 - Springer
Antibiotic natural products are ancient and so is resistance. Consequently, environmental
bacteria harbor numerous and varied antibiotic resistance elements. Nevertheless, despite …
bacteria harbor numerous and varied antibiotic resistance elements. Nevertheless, despite …
Lessons from the environmental antibiotic resistome
MD Surette, GD Wright - Annual review of microbiology, 2017 - annualreviews.org
Antibiotic resistance is a global public health issue of growing proportions. All antibiotics are
susceptible to resistance. The evidence is now clear that the environment is the single …
susceptible to resistance. The evidence is now clear that the environment is the single …
Origins and evolution of antibiotic resistance
J Davies, D Davies - Microbiology and molecular biology reviews, 2010 - Am Soc Microbiol
Antibiotics have always been considered one of the wonder discoveries of the 20th century.
This is true, but the real wonder is the rise of antibiotic resistance in hospitals, communities …
This is true, but the real wonder is the rise of antibiotic resistance in hospitals, communities …
Next-generation approaches to understand and combat the antibiotic resistome
Antibiotic resistance is a natural feature of diverse microbial ecosystems. Although recent
studies of the antibiotic resistome have highlighted barriers to the horizontal transfer of …
studies of the antibiotic resistome have highlighted barriers to the horizontal transfer of …
Solving the antibiotic crisis
GD Wright - ACS Infectious Diseases, 2015 - ACS Publications
Antibiotics are essential for both treating and preventing infectious diseases. Paradoxically,
despite their importance as pillars of modern medicine, we are in danger of losing antibiotics …
despite their importance as pillars of modern medicine, we are in danger of losing antibiotics …
[PDF][PDF] How to fight back against antibiotic resistance
G Dantas, MOA Sommer - Am Sci, 2014 - dantaslab.org
44 American Scientist, Volume 102 evolves in specific bacteria, as well as how it gets
passed between different bacteria and between different environments. We are still a long …
passed between different bacteria and between different environments. We are still a long …
Why do antibiotics exist?
F Spagnolo, M Trujillo, JJ Dennehy - MBio, 2021 - Am Soc Microbiol
In the struggle with antibiotic resistance, we are losing. There is now a serious threat of
moving into a postantibiotic world. High levels of resistance, in terms of both frequency and …
moving into a postantibiotic world. High levels of resistance, in terms of both frequency and …
Differential drivers of antimicrobial resistance across the world
Conspectus Antimicrobial resistance (AMR) is one of the greatest threats faced by
humankind. The development of resistance in clinical and hospital settings has been well …
humankind. The development of resistance in clinical and hospital settings has been well …