SPIROMICS protocol for multicenter quantitative computed tomography to phenotype the lungs

JP Sieren, JD Newell Jr, RG Barr… - American journal of …, 2016 - atsjournals.org
Multidetector row computed tomography (MDCT) is increasingly taking a central role in
identifying subphenotypes within chronic obstructive pulmonary disease (COPD), asthma …

Quantitative computed tomography in COPD: possibilities and limitations

OM Mets, PA De Jong, B Van Ginneken, HA Gietema… - Lung, 2012 - Springer
Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease that is
characterized by chronic airflow limitation. Unraveling of this heterogeneity is challenging …

Relationship between quantitative CT metrics and health status and BODE in chronic obstructive pulmonary disease

CH Martinez, YH Chen, PM Westgate, LX Liu, S Murray… - Thorax, 2012 - thorax.bmj.com
Background The value of quantitative CT (QCT) to identify chronic obstructive pulmonary
disease (COPD) phenotypes is increasingly appreciated. The authors hypothesised that …

Quantitative CT analysis of diffuse lung disease

A Chen, RA Karwoski, DS Gierada, BJ Bartholmai… - Radiographics, 2020 - pubs.rsna.org
Quantitative analysis of thin-section CT of the chest has a growing role in the clinical
evaluation and management of diffuse lung diseases. This heterogeneous group includes …

State of the Art. A structural and functional assessment of the lung via multidetector-row computed tomography: phenotyping chronic obstructive pulmonary disease

EA Hoffman, BA Simon, G McLennan - Proceedings of the American …, 2006 - atsjournals.org
With advances in multidetector-row computed tomography (MDCT), it is now possible to
image the lung in 10 s or less and accurately extract the lungs, lobes, and airway tree to the …

Pulmonary CT and MRI phenotypes that help explain chronic pulmonary obstruction disease pathophysiology and outcomes

EA Hoffman, DA Lynch, RG Barr… - Journal of Magnetic …, 2016 - Wiley Online Library
Pulmonary x‐ray computed tomographic (CT) and magnetic resonance imaging (MRI)
research and development has been motivated, in part, by the quest to subphenotype …

Quantitative CT assessment of chronic obstructive pulmonary disease

S Matsuoka, T Yamashiro, GR Washko, Y Kurihara… - Radiographics, 2010 - pubs.rsna.org
Chronic obstructive pulmonary disease (COPD) is characterized by the presence of airflow
limitation that is caused by a combination of small airway remodeling and emphysema …

Recent advances in computed tomography imaging in chronic obstructive pulmonary disease

S Bodduluri, JM Reinhardt, EA Hoffman… - Annals of the …, 2018 - atsjournals.org
Lung imaging is increasingly being used to diagnose, quantify, and phenotype chronic
obstructive pulmonary disease (COPD). Although spirometry is the gold standard for the …

Development of quantitative computed tomography lung protocols

JD Newell Jr, J Sieren, EA Hoffman - Journal of thoracic imaging, 2013 - journals.lww.com
The purpose of this review article is to review the process of developing optimal computed
tomography (CT) protocols for quantitative lung CT (QCT). In this review, we discuss the …

Parametric response mapping monitors temporal changes on lung CT scans in the subpopulations and intermediate outcome measures in COPD Study (SPIROMICS)

JL Boes, BA Hoff, M Bule, TD Johnson, A Rehemtulla… - Academic radiology, 2015 - Elsevier
Rationale and Objectives The longitudinal relationship between regional air trapping and
emphysema remains unexplored. We have sought to demonstrate the utility of parametric …