The PATCHED (PTC) gene encodes a Sonic hedgehog (Shh) receptor and a tumor
suppressor protein that is defective in basal cell nevus syndrome (BCNS). Functions of PTC …

Mutations in the tumor suppressor gene PATCHED (PTC) are found in human patients with
the basal cell nevus syndrome, a disease causing developmental defects and tumors …

The basal cell nevus syndrome (BCNS) is characterized by developmental abnormalities
and by the postnatal occurrence of cancers, especially basal cell carcinomas (BCCs), the …

Defects in a developmental signaling pathway involving mammalian homologues of the
Drosophila segment polarity gene, patched (ptc) and its ligand, sonic hedgehog (shh) …

Medulloblastoma (MB), a tumor of the cerebellum, is the most frequent type of malignant
childhood brain tumor. Multiple genes are causally involved in medulloblastoma including …

During early development in vertebrates, Sonic hedgehog (Shh) is produced by the
notochord and the floor plate. A ventrodorsal gradient of Shh directs ventrodorsal patterning …

The sonic hedgehog (SHH) signaling pathway directs the embryonic development of diverse
organisms and is disrupted in a variety of malignancies. Pathway activation is triggered by …

Targeted gene disruption in the mouse shows that the Sonic hedgehog (Shh) gene plays a
critical role in patterning of vertebrate embryonic tissues, including the brain and spinal cord …

The multitransmembrane protein Patched (PTCH) is the receptor for Sonic Hedgehog (Shh),
a secreted molecule implicated in the formation of embryonic structures and in …

Patched (Ptc) is a human tumor suppressor protein and a candidate receptor for Hedgehog
(Hh) proteins, which regulate growth and patterning in embryos. Ptc represses expression of …