Recent advances in growth hormone signaling

NJ Lanning, C Carter-Su - Reviews in Endocrine and Metabolic Disorders, 2006 - Springer
Growth hormone (GH) is a major regulatory factor for overall body growth as evidenced by
the height extremes in people with abnormal circulating GH levels or GH receptor (GHR) …

Growth hormone signalling and its regulation: preventing too much of a good thing

SJ Frank - Growth Hormone & IGF Research, 2001 - Elsevier
Growth hormone (GH) is a major growth-promoting and metabolic regulatory hormone.
Interaction of GH with its cell surface GH receptor (GHR), by virtue of receptor dimerization …

Mechanism of signaling by growth hormone receptor

LS Argetsinger, C Carter-Su - Physiological Reviews, 1996 - journals.physiology.org
Growth hormone (GH) has long been known to stimulate linear growth and regulate
metabolism. The cellular mechanism by which GH elicits these effects has only recently …

[HTML][HTML] The growth hormone receptor: mechanism of receptor activation, cell signaling, and physiological aspects

F Dehkhoda, CMM Lee, J Medina… - Frontiers in …, 2018 - frontiersin.org
The growth hormone receptor (GHR), although most well known for regulating growth, has
many other important biological functions including regulating metabolism and controlling …

Molecular mechanism of growth hormone action

C Carter-Su, J Schwartz, LJ Smit - Annual review of physiology, 1996 - annualreviews.org
Although the ability of growth hormone (GH) to stimulate body growth and regulate
metabolism has been recognized for many years, only recently has insight been gained into …

Growth hormone signaling pathways

C Carter-Su, J Schwartz, LS Argetsinger - Growth Hormone & IGF …, 2016 - Elsevier
Over 20 years ago, our laboratory showed that growth hormone (GH) signals through the GH
receptor-associated tyrosine kinase JAK2. We showed that GH binding to its membrane …

Negative regulation of growth hormone receptor signaling

A Flores-Morales, CJ Greenhalgh… - Molecular …, 2006 - academic.oup.com
GH has been of significant scientific interest for decades because of its capacity to
dramatically change physiological growth parameters. Furthermore, GH interacts with a …

Targeting growth hormone function: strategies and therapeutic applications

M Lu, JU Flanagan, RJ Langley, MP Hay… - Signal transduction and …, 2019 - nature.com
Human growth hormone (GH) is a classical pituitary endocrine hormone that is essential for
normal postnatal growth and has pleiotropic effects across multiple physiological systems …

Crosstalk between growth hormone and insulin signaling

J Xu, JL Messina - Vitamins & Hormones, 2009 - Elsevier
Growth Hormone (GH) is a major growth‐promoting and metabolic regulatory hormone.
Interaction of GH with its cell surface GH receptor (GHR) causes activation of the GHR …

Growth hormone signal transduction

G Piwien-Pilipuk, JS Huo, J Schwartz - Journal of Pediatric …, 2002 - degruyter.com
Multiple signaling pathways mediate the diverse effects of growth hormone (GH) on growth
and metabolism. The interaction of GH with GH receptors (GHR) on target cells promotes the …