[HTML][HTML] Effect of SARS-CoV-2 mutations on the efficacy of antibody therapy and response to vaccines

A Yaqinuddin, A Shafqat, J Kashir, K Alkattan - Vaccines, 2021 - mdpi.com
SARS-CoV-2 causes severe acute respiratory syndrome, which has led to significant
morbidity and mortality around the world. Since its emergence, extensive prophylactic and …

[HTML][HTML] Analysis of a SARS-CoV-2-infected individual reveals development of potent neutralizing antibodies with limited somatic mutation

E Seydoux, LJ Homad, AJ MacCamy, KR Parks… - Immunity, 2020 - cell.com
Antibody responses develop following SARS-CoV-2 infection, but little is known about their
epitope specificities, clonality, binding affinities, epitopes, and neutralizing activity. We …

The emergence of SARS-CoV-2 variants threatens to decrease the efficacy of neutralizing antibodies and vaccines

K Murano, Y Guo, H Siomi - Biochemical Society Transactions, 2021 - portlandpress.com
The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is
the cause of the coronavirus disease (COVID-19) pandemic. As of August 2021, more than …

[HTML][HTML] Anti-SARS-CoV-2 vaccines and monoclonal antibodies facing viral variants

A Chaqroun, C Hartard, E Schvoerer - Viruses, 2021 - mdpi.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is genetically variable,
allowing it to adapt to various hosts including humans. Indeed, SARS-CoV-2 has …

[HTML][HTML] Molecular variants of SARS-CoV-2: antigenic properties and current vaccine efficacy

A Rayati Damavandi, R Dowran, S Al Sharif… - Medical Microbiology …, 2022 - Springer
An ongoing pandemic of newly emerged SARS-CoV-2 has puzzled many scientists and
health care policymakers around the globe. The appearance of the virus was accompanied …

Antibodies elicited by mRNA-1273 vaccination bind more broadly to the receptor binding domain than do those from SARS-CoV-2 infection

AJ Greaney, AN Loes, LE Gentles… - Science translational …, 2021 - science.org
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants
with mutations in key antibody epitopes has raised concerns that antigenic evolution could …

SARS-CoV-2 variants B. 1.351 and B. 1.1. 248: Escape from therapeutic antibodies and antibodies induced by infection and vaccination

M Hoffmann, P Arora, R Groß, A Seidel, B Hörnich… - BioRxiv, 2021 - biorxiv.org
The global spread of SARS-CoV-2/COVID-19 is devastating health systems and economies
worldwide. Recombinant or vaccine-induced neutralizing antibodies are used to combat the …

[HTML][HTML] A critical overview of current progress for COVID-19: development of vaccines, antiviral drugs, and therapeutic antibodies

M Kumari, RM Lu, MC Li, JL Huang, FF Hsu… - Journal of biomedical …, 2022 - Springer
The novel coronavirus disease (COVID-19) pandemic remains a global public health crisis,
presenting a broad range of challenges. To help address some of the main problems, the …

Effects of SARS-CoV-2 variants on vaccine efficacy and response strategies

L Bian, F Gao, J Zhang, Q He, Q Mao, M Xu… - Expert review of …, 2021 - Taylor & Francis
Introduction As the global severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
pandemic continues to spread, several variants have emerged. Variants B. 1.1. 7 and B …

[HTML][HTML] Resistance of SARS-CoV-2 variants to neutralization by antibodies induced in convalescent patients with COVID-19

Y Kaku, T Kuwata, HM Zahid, T Hashiguchi, T Noda… - Cell reports, 2021 - cell.com
Administration of convalescent plasma or neutralizing monoclonal antibodies (mAbs) is a
potent therapeutic option for coronavirus disease 2019 (COVID-19) caused by severe acute …