Obesity is a growing public health problem worldwide, and GH and IGF-1 have been studied
as potential therapeutic targets for managing this condition. This review article aims to …

Obesity has become one of the most common medical problems in developed countries,
and this disorder is associated with high incidences of hypertension, dyslipidaemia …

Growth hormone (GH), a master regulator of somatic growth, also regulates carbohydrate
and lipid metabolism via complex interactions with insulin and insulin-like growth factor-1 …

The cluster of cardiovascular risk factors—abdominal obesity, dyslipidaemia, insulin
resistance and hypertension—has been recognized as the core of the metabolic syndrome …

There is substantial evidence that the growth hormone (GH)/insulin-like growth factor (IGF)
system is involved in the pathophysiology of obesity. Both GH and IGF-I have direct effects …

Abstract Purpose of Review Canonical growth hormone (GH)-dependent signaling is
essential for growth and counterregulatory responses to hypoglycemia, but also may …

In this review we propose an integrated neuro-endocrine-metabolic point of view on the
alterations (adaptations?) of GH/IGF-1 axis in obesity, summarizing the evidence from the …

In addition to its major role in the regulation of somatic growth, growth hormone (GH)
signaling has profound effects on function of various tissues in the body. However, the …

Obesity is an excessive accumulation or expansion of adipose tissue (AT) due to an
increase in either the size and/or number of its characteristic cell type, the adipocyte. As one …

GH exerts a diverse array of physiological actions that include prominent roles in growth and
metabolism, with a major contribution via stimulating IGF-1 synthesis. GH achieves its effects …