[HTML][HTML] Overcoming the pulmonary barrier: New insights to improve the efficiency of inhaled therapeutics

X Murgia, C de Souza Carvalho… - European Journal of …, 2014 - degruyter.com
The pulmonary route offers an exceptional, non-invasive administration site for drug
delivery. The principal characteristics that make the lungs an appealing route for drug …

Pulmonary drug delivery: a role for polymeric nanoparticles?

I d'Angelo, C Conte, A Miro, F Quaglia… - Current Topics in …, 2015 - ingentaconnect.com
Pulmonary drug delivery represents the best way of treating lung diseases, since it allows
direct delivery of the drug to the site of action, with few systemic effects. Meanwhile, the …

The nanoscale in pulmonary delivery. Part 1: deposition, fate, toxicology and effects

PGA Rogueda, D Traini - Expert opinion on drug delivery, 2007 - Taylor & Francis
This two-part review explores the nanoscale in inhalation delivery. The first part covers the
deposition, fate, toxicity and effects of nanoparticles delivered via inhalation. The second …

Therapeutic nanostructures for pulmonary drug delivery

Y Javadzadeh, S Yaqoubi - Nanostructures for drug delivery, 2017 - Elsevier
Pulmonary drug delivery has attracted tremendous interest in the past two decades. In order
to get both local and systemic effects, lungs as the main part of the respiratory system offer …

Nanoparticles: characteristics, mechanisms of action, and toxicity in pulmonary drug delivery—a review

S Gill, R Löbenberg, T Ku, S Azarmi… - Journal of …, 2007 - ingentaconnect.com
The pulmonary route has recently gained momentum as a suitable avenue for drug delivery.
The large alveolar surface area of approximately 75 m2 coupled with the thin epithelial …

Pulmonary drug delivery: from generating aerosols to overcoming biological barriers—therapeutic possibilities and technological challenges

CA Ruge, J Kirch, CM Lehr - The lancet Respiratory medicine, 2013 - thelancet.com
Research in pulmonary drug delivery has focused mainly on new particle or device
technologies to improve the aerosol generation and pulmonary deposition of inhaled drugs …

Inhaled nano-and microparticles for drug delivery

IM El-Sherbiny, NM El-Baz, MH Yacoub - Global Cardiology Science …, 2015 - qscience.com
The 21st century has seen a paradigm shift to inhaled therapy, for both systemic and local
drug delivery, due to the lung's favourable properties of a large surface area and high …

Inhaled drug delivery: Past, present, and future

L Yue, X Zhang, C Zhao, R Chen, X Chen, L Rao - Nano Today, 2023 - Elsevier
Inhaled drug delivery has been an emerging route for the treatment of lung diseases with
clear advantages over oral and intravenous routes. However, the delivery efficacy is affected …

Inhalative nanomedicine—opportunities and challenges

M Bur, A Henning, S Hein, M Schneider… - Inhalation …, 2009 - Taylor & Francis
Inhalation therapy is still limited by the low bioavailability of the administered drugs.
Advantages of the pulmonary administration site like large resorption area, low enzymatic …

Nano-delivery to the lung-by inhalation or other routes and why nano when micro is largely sufficient?

V Forest, J Pourchez - Advanced Drug Delivery Reviews, 2022 - Elsevier
Respiratory diseases gather a wide range of disorders which are generally difficult to treat,
partly due to a poor delivery of drugs to the lung with adequate dose and minimum side …