Tardive dyskinesia is caused by maladaptive synaptic plasticity: a hypothesis

JT Teo, MJ Edwards, K Bhatia - Movement Disorders, 2012 - Wiley Online Library
It has been 50 years since the first patients with tardive dyskinesia (TD) were described, but
the pathophysiology is only partially understood and effective treatments have remained …

Historical perspectives on tardive dyskinesia

SN Caroff, GS Ungvari, DGC Owens - Journal of the neurological sciences, 2018 - Elsevier
Tardive dyskinesia (TD) is a persistent hyperkinetic movement disorder associated with
dopamine receptor blocking agents including antipsychotic medications. Although …

Pathophysiological mechanisms underlying tardive dyskinesia

J Gerlach - Dyskinesia: research and treatment, 1985 - Springer
The pathophysiology of TD is still not clear, and the traditional dopamine (DA)
hypersensitivity model seems inadequate. Animal experiments suggest that blockade of …

Neuronal traffic signals in tardive dyskinesia: not enough “stop” in the motor striatum

SM Stahl - CNS spectrums, 2017 - cambridge.org
Neuronal traffic signals in tardive dyskinesia: not enough “stop” in the motor striatum Page 1
Neuronal traffic signals in tardive dyskinesia: not enough “stop” in the motor striatum Stephen …

Tardive dyskinesia (syndrome): current concept and modern approaches to its management

PP Lerner, C Miodownik… - Psychiatry and clinical …, 2015 - Wiley Online Library
Tardive dyskinesia is a serious, disabling and potentially permanent, neurological
hyperkinetic movement disorder that occurs after months or years of taking psychotropic …

Treatment of tardive dyskinesia: a general overview with focus on the vesicular monoamine transporter 2 inhibitors

N Niemann, J Jankovic - Drugs, 2018 - Springer
Tardive dyskinesia (TD) encompasses the spectrum of iatrogenic hyperkinetic movement
disorders following exposure to dopamine receptor-blocking agents (DRBAs). Despite the …

[HTML][HTML] Recent advances in the pharmacology of tardive dyskinesia

SN Caroff - Clinical Psychopharmacology and Neuroscience, 2020 - ncbi.nlm.nih.gov
Tardive dyskinesia (TD) is a syndrome of abnormal involuntary movements that follows
treatment with dopamine D2-receptor antagonists. Recent approval of vesicular monoamine …

[HTML][HTML] Tardive dyskinesia: therapeutic options for an increasingly common disorder

LJ Cloud, D Zutshi, SA Factor - Neurotherapeutics, 2014 - Elsevier
Tardive dyskinesia (TD) is a serious, often disabling, movement disorder that is caused by
medications that block dopamine receptors (ie, neuroleptics, anti-emetics). There is currently …

Tardive dyskinesia: Who gets it and why

K Frei - Parkinsonism & Related Disorders, 2019 - Elsevier
Tardive dyskinesia (TD) is a potentially permanent movement disorder resulting from chronic
use of dopamine receptor blocking agents (DRBA). Identified risk factors include the type of …

A unifying theory for the pathoetiologic mechanism of tardive dyskinesia

Z Ali, A Roque, RS El-Mallakh - Medical Hypotheses, 2020 - Elsevier
Introduction Chronic treatment with dopamine D2 receptor antagonists has been proposed
to lead to dopamine receptor supersensitivity. Frequently, this is conceptualized as …