Alzheimer's disease (AD) represents one of the most common and debilitating
neurodegenerative disorders. By the end of 2040, AD patients might reach 11.2 million in …

In this review, we shed light on recent advances regarding the characterization of
biochemical pathways of cellular mechanosensing and mechanotransduction with particular …

Just as the epigenome, the proteome and the electrophysiological properties of a cell
influence its function, so too do its intrinsic mechanical properties and its extrinsic …

The activation of microglia, the inflammatory cells of the central nervous system (CNS), has
been linked to the pathogenesis of Alzheimer's disease and other neurodegenerative …

Alzheimer disease is a progressive neurodegenerative disorder, mainly affecting older
people, which severely impairs patients' quality of life. In the recent years, the number of …

The pathogenesis of neurodegenerative disorders, including Alzheimer's disease, has been
studied with a focus on biochemical mechanisms, such as the amyloid-β plaque deposition …

Microglial cells are the key immunocompetent cells in the central nervous system (CNS) and
play a crucial role in CNS health and disease (Paolicelli et al., 2022). Under the homeostatic …

Traumatic brain injury (TBI) is a worldwide health and socioeconomic problem, associated
with prolonged and complex neurological aftermaths, including a variety of functional deficits …

Cells are continuously exposed to physical forces and the central nervous system (CNS) is
no exception. Cells dynamically adapt their behavior and remodel the surrounding …

Therapeutic strategies aimed at overcoming the loss of myelin sheath in central nervous
system demyelinating diseases are often unsuccessful due to nescience underlying the …