Habitual actions, which are associated with addictive behaviours, contribute to the loss of
control of food seeking seen following exposure to calorie-dense foods in rats. Antagonism …

The orexins are widely regarded potential therapeutic targets for a range of disorders of
appetitive motivation, including obesity. The motivational activator theory, the first coherent …

Orexins (OX) and their receptors (OXR) modulate feeding, arousal, stress, and drug abuse.
Neural systems that motivate and reinforce drug abuse may also underlie compulsive food …

Rationale Brain orexin 1 receptors (OX1Rs) are involved in food-motivated behavior. Most
research has focused on forebrain OX1R populations, but hindbrain OX1Rs affect feeding …

In rodents, orexin neuropeptides regulate motivation and reward-seeking via orexin 1
receptor (OX1R) signaling in the mesolimbic dopaminergic system. This role is clearly …

The orexin/hypocretin (ORX) system plays a major role in motivation for natural and drug
rewards. In particular, a number of studies have shown that ORX signaling through the …

A role for orexin A in mediating the primary and conditioned reinforcing effects of alcohol has
been established. It is unclear however whether the contribution of orexins to alcohol reward …

BACKGROUND: Orexin (hypocretin) signaling is implicated in drug addiction and reward,
but its role in feeding and food-motivated behavior remains unclear. METHODS: We …

The orexin (OX) system has been implicated in food-reinforced behavior, food-seeking and
food overconsumption. Recent evidence suggests that OX signaling might influence …

Work from our laboratory has shown that orexin (ORX; or hypocretin) neurons in the lateral
hypothalamus are involved in preference for morphine, cocaine, and food. Other groups …