Neuronal activity drives alterations in gene expression within neurons, yet how it directs
transcriptional and epigenomic changes in neighboring astrocytes in functioning circuits is …

The influence that neurons exert on astrocytic function is poorly understood. To investigate
this, we first developed a system combining cortical neurons and astrocytes from closely …

Astrocytes play central roles in normal brain function and are critical components of synaptic
networks that oversee behavioral outputs. Despite their close affiliation with neurons, how …

Multimodal astrocyte–neuron communications govern brain circuitry assembly and function.
For example, through rapid glutamate release, astrocytes can control excitability, plasticity …

The role of transcription factors during astrocyte development and their subsequent effects
on neuronal development has been well studied. Less is known about astrocytes …

Olfaction depends on lifelong production of sensory neurons from CXCR4 expressing
neurogenic stem cells. Signaling by CXCR4 depends on the concentration of CXCL12 …

There is a high prevalence of behavioral disorders that feature hyperactivity in individuals
with severe inner ear dysfunction. What remains unknown is whether inner ear dysfunction …

INTRODUCTION The diversity of cell types is a defining feature of the neuronal circuitry that
makes up the areas and layers of the mammalian cortex. At a molecular level, the extent of …

Astrocytes actively participate in synaptic integration by releasing transmitter (glutamate) via
a calcium-regulated, exocytosis-like process. Here we show that this process follows …

Extrinsic signaling between diverse cell types is crucial for nervous system development.
Ligand binding is a key driver of developmental processes. Nevertheless, it remains a …