Chromosomal inversion between 3q21 and 3q26 results in high-risk acute myeloid leukemia
(AML). In this study, we identified a mechanism whereby a GATA2 distal hematopoietic …

Chromosomal rearrangements without gene fusions have been implicated in
leukemogenesis by causing deregulation of proto-oncogenes via relocation of cryptic …

EVI1, located at chromosome band 3q26, encodes a 1051 amino acid zinc finger protein
inappropriately expressed in the leukemic cells of 2–5% of acute myeloid leukemia (AML) …

Acute myeloid leukemia (AML) with inv (3)/t (3; 3)(q21q26) is a distinct World Health
Organization recognized entity, characterized by its aggressive course and poor prognosis …

In acute myeloid leukemia (AML) with inv (3)(q21; q26) or t (3; 3)(q21; q26), a translocated
GATA2 enhancer drives oncogenic expression of EVI1. We generated an EVI1-GFP AML …

The ecotropic viral integration site‐1 (Evi1) is an oncogenic transcription factor in murine
and human myeloid leukemia. We herein show that Evi1 is predominantly expressed in …

Chromosomal rearrangements are a frequent cause of oncogene deregulation in human
malignancies. Overexpression of EVI1 is found in a subgroup of acute myeloid leukemia …

Deregulated expression of the ecotropic virus integration site 1 (EVI 1) gene is the molecular
hallmark of therapy‐resistant myeloid malignancies bearing chromosomal inv (3)(q21q26· 2) …

Cis-element encyclopedias provide information on phenotypic diversity and disease
mechanisms. Although cis-element polymorphisms and mutations are instructive …

The proto-oncogene EVI1 (ecotropic viral integration site-1), located on chromosome band
3q26, is aberrantly expressed in human acute myeloid leukemia (AML) with 3q26 …