Acromegaly pathogenesis and treatment

S Melmed - The Journal of clinical investigation, 2009 - Am Soc Clin Investig
Dysregulated growth hormone (GH) hypersecretion is usually caused by a GH-secreting
pituitary adenoma and leads to acromegaly—a disorder of disproportionate skeletal, tissue …

[引用][C] Clinical review 75: recent advances in pathogenesis, diagnosis, and management of acromegaly

S Melmed, K Ho, A Klibanski, S Reichlin… - The Journal of …, 1995 - academic.oup.com
The CLINICAL consequences of advanced acromegaly are disfigurement, disability, and
shortened life expectancy due to respiratory, metabolic, cardiovascular, and malignant …

Guidelines for acromegaly management

S Melmed, FF Casanueva, F Cavagnini… - The Journal of …, 2002 - academic.oup.com
Acromegaly is an insidious disorder caused by a pituitary GH-secreting adenoma resulting
in high circulating levels of GH and IGF-I (1). Unfortunately, no single therapy is …

Acromegaly

S Melmed - The pituitary, 2017 - Elsevier
Acromegaly is caused by excess growth hormone (GH) secretion emanating from a
somatotroph adenoma. High GH and Insulin-like growth factor-1 (IGF-1) levels lead to acral …

Acromegaly

A Colao, LFS Grasso, A Giustina, S Melmed… - Nature Reviews …, 2019 - nature.com
Acromegaly is characterized by increased release of growth hormone and, consequently,
insulin-like growth factor I (IGF1), most often by a pituitary adenoma. Prolonged exposure to …

Medical therapy in acromegaly

M Sherlock, C Woods, MC Sheppard - Nature Reviews Endocrinology, 2011 - nature.com
Acromegaly is a rare disease characterized by excess secretion of growth hormone (GH)
and increased circulating insulin-like growth factor 1 (IGF-1) concentrations. The disease is …

Current treatment guidelines for acromegaly

S Melmed, I Jackson, D Kleinberg… - The Journal of Clinical …, 1998 - academic.oup.com
abstract Acromegaly, an indolent disorder of growth hormone (GH) hypersecretion is most
typically caused by a somatotroph cell adenoma and may be treated by several modalities …

The changing face of acromegaly—advances in diagnosis and treatment

A Ribeiro-Oliveira Jr, A Barkan - Nature Reviews Endocrinology, 2012 - nature.com
Acromegaly is a chronic disease characterized by the presence of a pituitary growth
hormone (GH)-producing tumour, excessive secretion of growth hormone, raised levels of …

Clinical perspective: acromegaly and cancer: not a problem?

S Melmed - The Journal of Clinical Endocrinology & Metabolism, 2001 - academic.oup.com
Acromegaly is usually caused by a GH-secreting pituitary adenoma. Somatic growth and
metabolic dysfunction occur subsequent to unrestrained GH secretion and elevated insulin …

Acromegaly

A Ben-Shlomo, S Melmed - Endocrinology and metabolism clinics of North …, 2008 - Elsevier
Acromegaly is a rare disease caused by growth hormone hypersecretion, mostly from a
pituitary adenoma, driving insulin-like growth factor 1 overproduction. Manifestations include …