The cell intrinsic antiviral response of multicellular organisms developed over millions of
years and critically relies on the ability to sense and eliminate viral nucleic acids. Here we …

Abstract TBK1, STING, and MDA5 are important players within the antiviral innate immune
response network. We mapped the interactome of endogenous TBK1, STING, and MDA5 by …

Viruses encode transcriptional regulatory proteins critical for controlling viral and host gene
expression. Given their multifunctional nature and high sequence divergence, it is unclear …

A diverse subset of pattern recognition receptors (PRRs) detects pathogen-associated
nucleic acids to initiate crucial innate immune responses in host organisms. Reflecting their …

The current therapeutic arsenal against viral infections remains limited, with often poor
efficacy and incomplete coverage, and appears inadequate to face the emergence of drug …

Mammalian genes and genomes have been shaped by ancient and ongoing challenges
from viruses. These genetic imprints can be identified via evolutionary analyses to reveal …

The primary interactions between incoming viral RNA genomes and host proteins are crucial
to infection and immunity. Until now, the ability to study these events was lacking. We …

During viral infection, virus-derived cytosolic nucleic acids are recognized by host
intracellular specific sensors. The efficacy of this recognition system is crucial for triggering …

Infectious diseases result in millions of deaths each year. Mechanisms of infection have
been studied in detail for many pathogens. However, many questions are relatively …

Viruses require host cellular factors for successful replication. A comprehensive systems-
level investigation of the virus-host interactome is critical for understanding the roles of host …