Mice lacking the p110δ catalytic subunit of phosphatidylinositol 3-kinase have reduced
numbers of B1 and marginal zone B cells, reduced levels of serum immunoglobulins …

Many receptor and nonreceptor tyrosine kinases activate phosphoinositide 3-kinases
(PI3Ks). To assess the role of the δ isoform of the p110 catalytic subunit of PI3Ks, we derived …

Mice with a targeted gene disruption of p85α, a regulatory subunit of phosphoinositide 3-
kinase, had impaired B cell development at the pro–B cell stage, reduced numbers of …

Mouse gene–targeting studies have documented a central role of the p110δ isoform of
phosphoinositide 3-kinase (PI3K) in B-cell development and function. A defect in B-cell …

The role of PI3K activity in T lymphocyte development is obscure because mice deficient in
single PI3K catalytic subunits either die before birth (p110α−/− and p110β−/−) or lack a …

B-1 and marginal zone (MZ) B cells produce natural Abs, make Ab responses to microbial
pathogens, and contribute to autoimmunity. Although the δ isoform of the PI3K p110 catalytic …

Signal transduction through the B-cell antigen receptor (BCR) determines the fate of B
lymphocytes during their development and during immune responses. A multitude of signal …

A variety of genetic and inhibitor studies have shown that phosphoinositide 3-kinase γ
(PI3Kγ) plays an essential role in a number of physiological responses, including neutrophil …

B cell development is controlled by a series of checkpoints that ensure that the
immunoglobulin (Ig)–encoding genes produce a functional B cell receptor (BCR) and …

Class IA phosphoinositide 3-kinases (PI3Ks) are a family of p85/p110 heterodimeric lipid
kinases that generate second messenger signals downstream of tyrosine kinases, thereby …