Eukaryotic genomes are organized into condensed, heterogeneous chromatin fibers
throughout much of the cell cycle. Here we describe recent studies indicating that even …

How activators regulate gene tran-scription has been hotly debated for more than a decade
(1). Initial studies suggested that activator proteins bound to the promoter of the target gene …

Whereas folding of genomes at the large scale of epigenomic compartments and
topologically associating domains (TADs) is now relatively well understood, how chromatin …

Genomic DNA in the eukaryotic nucleus is hierarchically packaged by histones into
chromatin to fit inside the nucleus. The dynamics of higher-order chromatin compaction play …

New methods for the genome-wide analysis of chromatin are providing insight into its roles
in development and their underlying mechanisms. Current studies indicate that chromatin is …

Chromatin, the physiological template of all eukaryotic genetic information, is subject to a
diverse array of posttranslational modifications that largely impinge on histone amino …

The compaction of DNA into chromatin in the eukaryotic nucleus poses many obstacles to
transcription. Individual nucleosomes as well as higher order structures limit access of cis …

DNA supercoiling is an inherent consequence of twisting DNA and is critical for regulating
gene expression and DNA replication. However, DNA supercoiling at a genomic scale in …

INTRODUCTION Chromatin adopts an intricate three-dimensional (3D) organization in the
nucleus that is critical for many genome processes, from gene regulation to genome …

Although it is believed that the interconversion between permissive and refractory chromatin
structures is important in regulating gene transcription, this process is poorly understood …