Successful antitumor immunity largely relies on efficient T cell priming by antigen-presenting
cells (APCs); however, the capacity of APCs is found to be defective in many cancers …

Cancer metabolic reprogramming has been considered an emerging hallmark in
tumorigenesis and the antitumor immune response. Like cancer cells, immune cells within …

Malignant cells upregulate distinct energy metabolism programs that support their
proliferation, migration, and adaptation to the stressful tumor microenvironment (TME) …

Advances in immunotherapy have underscored the importance of antitumor immune
responses in controlling cancer. However, the tumor microenvironment (TME) imposes …

Cellular metabolism is not only essential for tumor cells to sustain their rapid growth and
proliferation, but also crucial to maintain T cell fitness and robust immunity. Dysregulated …

The development of immunotherapies over the past decade has resulted in a paradigm shift
in the treatment of cancer. However, the majority of patients do not benefit from …

Cellular metabolism of both cancer and immune cells in the acidic, hypoxic, and nutrient-
depleted tumor microenvironment (TME) has attracted increasing attention in recent years …

Immunometabolism is an emerging discipline in cancer immunotherapy. Tumor tissues are
heterogeneous and influenced by metabolic reprogramming of the tumor immune …

Cytotoxic T lymphocytes and NK cells play an important role in eliminating malignant tumor
cells and the number and activity of tumor-infiltrating T cells represent a good marker for …

Immunotherapy shifted the paradigm of cancer treatment. The clinical approval of immune
checkpoint blockade and adoptive cell transfer led to considerable success in several tumor …