Identifying protein pockets suitable for small-molecule engagement is a critical part of early
drug discovery. Enzymes that operate on or with small molecule cofactors and G-protein …

This Perspective explores molecular glues and bifunctional compounds—proximity-inducing
compounds—and offers a framework to understand and exploit their similarity to hotspots …

Following sequencing and assembly of the human genome, the preferred methods for
identification of new drug targets have changed dramatically. Modern tactics such as …

Protein–protein interactions (PPIs) control the assembly of multi-protein complexes and,
thus, these contacts have enormous potential as drug targets. However, the field has …

Protein–protein interactions (PPIs) are involved in many biological processes, with an
estimated 400,000 PPIs within the human proteome. There is significant interest in exploiting …

The modulation of protein-protein interactions with small molecules is one of the most
rapidly developing areas in drug discovery. In this review, we discuss advances over the …

Protein-protein interactions (PPIs) are ubiquitous biomolecular processes that are central to
virtually all aspects of cellular function. Identifying small molecules that modulate specific …

Because of the key relevance of protein–protein interactions (PPI) in diseases, the
modulation of protein-protein complexes is of relevant clinical significance. The successful …

Drug medications inevitably affect not only their intended protein targets but also other
proteins as well. In this study we examined the hypothesis that drugs that share the same …