One-carbon metabolism involving the folate and methionine cycles integrates nutritional
status from amino acids, glucose and vitamins, and generates diverse outputs, such as the …

Serine/glycine biosynthesis and one-carbon metabolism are crucial in sustaining cancer cell
survival and rapid proliferation, and of high clinical relevance. Excessive activation of …

Folate metabolism functions to supply one-carbon units that are vital for a range of
biochemical reactions. Cancer cells can utilise serine as a major source of one-carbon units …

Cells require one-carbon units for nucleotide synthesis, methylation and reductive
metabolism, and these pathways support the high proliferative rate of cancer cells. As such …

Highlights•Cellular metabolism is reprogrammed to support tumorigenesis.•Folate fulfill
many metabolic requirements of proliferating cells and relevant metabolic pathway affect …

Serine and glycine are biosynthetically linked, and together provide the essential precursors
for the synthesis of proteins, nucleic acids, and lipids that are crucial to cancer cell growth …

Folate metabolism supplies one-carbon (1C) units for biosynthesis and methylation and has
long been a target for cancer chemotherapy. Mitochondrial serine catabolism is considered …

Cancer is a disease characterized by unrestrained cellular proliferation. In order to sustain
growth, cancer cells undergo a complex metabolic rearrangement characterized by changes …

The non-essential amino acid serine supports several metabolic processes that are crucial
for the growth and survival of proliferating cells, including protein, amino acid and …

Metabolic pathways leading to the synthesis, uptake, and usage of the nonessential amino
acid serine are frequently amplified in cancer. Serine encounters diverse fates in cancer …