Four-factor prothrombin complex concentrate is associated with improved survival in trauma-related hemorrhage: a nationwide propensity-matched analysis
METHODS Two-year (2015–2016) analysis of the American College of Surgeons-Trauma
Quality Improvement Program database. All adult (age≥ 18 years) trauma patients who …
Quality Improvement Program database. All adult (age≥ 18 years) trauma patients who …
The role of four-factor prothrombin complex concentrate in coagulopathy of trauma: a propensity matched analysis
BACKGROUND Coagulopathy is a common complication after severe trauma. The efficacy
of 4-factor prothrombin complex concentrate (4-PCC) as an adjunct to fresh frozen plasma …
of 4-factor prothrombin complex concentrate (4-PCC) as an adjunct to fresh frozen plasma …
Efficacy and safety of early administration of 4-factor prothrombin complex concentrate in patients with trauma at risk of massive transfusion: the PROCOAG …
P Bouzat, J Charbit, PS Abback, D Huet-Garrigue… - Jama, 2023 - jamanetwork.com
Importance Optimal transfusion strategies in traumatic hemorrhage are unknown. Reports
suggest a beneficial effect of 4-factor prothrombin complex concentrate (4F-PCC) on blood …
suggest a beneficial effect of 4-factor prothrombin complex concentrate (4F-PCC) on blood …
[HTML][HTML] Prothrombin complex concentrate for trauma induced coagulopathy: a systematic review and meta-analysis
TW Kao, YC Lee, HT Chang - Journal of acute medicine, 2021 - ncbi.nlm.nih.gov
Background Optimal management for trauma-induced coagulopathy (TIC) is a clinical
conundrum. In conjunction with the transfusion of fresh-frozen plasma (FFP), additional …
conundrum. In conjunction with the transfusion of fresh-frozen plasma (FFP), additional …
Prothrombin complex concentrate versus fresh‐frozen plasma for reversal of coagulopathy of trauma: is there a difference?
Introduction The development of coagulopathy of trauma is multifactorial associated with
hypoperfusion and consumption of coagulation factors. Previous studies have compared the …
hypoperfusion and consumption of coagulation factors. Previous studies have compared the …
[HTML][HTML] Prothrombin complex concentrate (PCC) for treatment of trauma-induced coagulopathy: systematic review and meta-analyses
I Hannadjas, A James, R Davenport, C Lindsay… - Critical Care, 2023 - Springer
Background Trauma-induced coagulopathy (TIC) is common in trauma patients with major
hemorrhage. Prothrombin complex concentrate (PCC) is used as a potential treatment for …
hemorrhage. Prothrombin complex concentrate (PCC) is used as a potential treatment for …
Four-factor prothrombin complex concentrate for life-threatening bleeds or emergent surgery: a retrospective evaluation
JH Sin, K Berger, CA Lesch - Journal of critical care, 2016 - Elsevier
Purpose Previous trials investigating usage of four-factor prothrombin complex concentrate
(4F-PCC) excluded patients with various thrombotic risk factors. The objective of this study …
(4F-PCC) excluded patients with various thrombotic risk factors. The objective of this study …
Is there a difference in efficacy, safety, and cost-effectiveness between 3-factor and 4-factor prothrombin complex concentrates among trauma patients on oral …
A Mangram, OF Oguntodu, JK Dzandu… - Journal of critical …, 2016 - Elsevier
Purpose The aim of this study was to compare the efficacy, safety, and cost-effectiveness of
3-factor prothrombin complex concentrate (3F-PCC) vs 4-factor prothrombin complex …
3-factor prothrombin complex concentrate (3F-PCC) vs 4-factor prothrombin complex …
The exclusive use of coagulation factor concentrates enables reversal of coagulopathy and decreases transfusion rates in patients with major blunt trauma
P Innerhofer, I Westermann, H Tauber, R Breitkopf… - Injury, 2013 - Elsevier
BACKGROUND: FFP and coagulation factor concentrates are used to correct trauma-
induced coagulopathy (TIC). However, data on coagulation profiles investigating effects of …
induced coagulopathy (TIC). However, data on coagulation profiles investigating effects of …
The clinical use of prothrombin complex concentrate
J Ferreira, M DeLosSantos - The Journal of emergency medicine, 2013 - Elsevier
BACKGROUND: Prothrombin complex concentrate (PCC) is an inactivated concentrate of
factors II, IX, and X, with variable amounts of factor VII. Guidelines recommend the use of …
factors II, IX, and X, with variable amounts of factor VII. Guidelines recommend the use of …