METHODS Two-year (2015–2016) analysis of the American College of Surgeons-Trauma
Quality Improvement Program database. All adult (age≥ 18 years) trauma patients who …

BACKGROUND Coagulopathy is a common complication after severe trauma. The efficacy
of 4-factor prothrombin complex concentrate (4-PCC) as an adjunct to fresh frozen plasma …

Importance Optimal transfusion strategies in traumatic hemorrhage are unknown. Reports
suggest a beneficial effect of 4-factor prothrombin complex concentrate (4F-PCC) on blood …

Background Optimal management for trauma-induced coagulopathy (TIC) is a clinical
conundrum. In conjunction with the transfusion of fresh-frozen plasma (FFP), additional …

Introduction The development of coagulopathy of trauma is multifactorial associated with
hypoperfusion and consumption of coagulation factors. Previous studies have compared the …

Background Trauma-induced coagulopathy (TIC) is common in trauma patients with major
hemorrhage. Prothrombin complex concentrate (PCC) is used as a potential treatment for …

Purpose Previous trials investigating usage of four-factor prothrombin complex concentrate
(4F-PCC) excluded patients with various thrombotic risk factors. The objective of this study …

Purpose The aim of this study was to compare the efficacy, safety, and cost-effectiveness of
3-factor prothrombin complex concentrate (3F-PCC) vs 4-factor prothrombin complex …

BACKGROUND: FFP and coagulation factor concentrates are used to correct trauma-
induced coagulopathy (TIC). However, data on coagulation profiles investigating effects of …

BACKGROUND: Prothrombin complex concentrate (PCC) is an inactivated concentrate of
factors II, IX, and X, with variable amounts of factor VII. Guidelines recommend the use of …