[HTML][HTML] Drug discovery targeting focal adhesion kinase (FAK) as a promising cancer therapy

XJ Pang, XJ Liu, Y Liu, WB Liu, YR Li, GX Yu, XY Tian… - Molecules, 2021 - mdpi.com
FAK is a nonreceptor intracellular tyrosine kinase which plays an important biological
function. Many studies have found that FAK is overexpressed in many human cancer cell …

Progress in the development of small molecular inhibitors of focal adhesion kinase (FAK)

Y Lu, H Sun - Journal of Medicinal Chemistry, 2020 - ACS Publications
Focal adhesion kinase (FAK) is a nonreceptor intracellular tyrosine kinase that plays an
essential role in cancer cell adhesion, survival, proliferation, and migration through both its …

Focal adhesion kinase—An emerging viable target in cancer and development of focal adhesion kinase inhibitors

A Chauhan, T Khan - Chemical biology & drug design, 2021 - Wiley Online Library
Focal adhesion kinase (FAK) is a non‐receptor tyrosine kinase located at the extracellular
matrix cell adhesion site. This kinase mediates downstream signalling cascades on the cell …

[HTML][HTML] Focal adhesion kinase inhibitors, a heavy punch to cancer

Y Wu, N Li, C Ye, X Jiang, H Luo, B Zhang, Y Zhang… - Discover Oncology, 2021 - Springer
Kinases are the ideal druggable targets for diseases and especially were highlighted on
cancer therapy. Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase and its …

Development and Characterization of Selective FAK Inhibitors and PROTACs with In Vivo Activity

E Koide, ML Mohardt, ZM Doctor, A Yang… - …, 2023 - Wiley Online Library
Focal adhesion kinase (FAK) is an attractive drug target due to its overexpression in cancer.
FAK functions as a non‐receptor tyrosine kinase and scaffolding protein, coordinating …

FAK inhibitors in Cancer, a patent review

PC Lv, AQ Jiang, WM Zhang, HL Zhu - Expert opinion on …, 2018 - Taylor & Francis
Introduction: Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that localizes at
sites of cell adhesion to the extracellular matrix (ECM) and mediates signalling events …

Structure-based design, synthesis, and characterization of the first irreversible inhibitor of focal adhesion kinase

E Yen-Pon, B Li… - ACS Chemical …, 2018 - ACS Publications
Focal Adhesion Kinase signaling pathway and its functions have been involved in the
development and aggressiveness of tumor malignancy, it then presents a promising cancer …

FAK-targeted and combination therapies for the treatment of cancer: an overview of phase I and II clinical trials

A Mohanty, RR Pharaon, A Nam, S Salgia… - Expert opinion on …, 2020 - Taylor & Francis
Introduction: Focal adhesion kinase (FAK) is a promising target for the treatment of solid
tumors because its expression has been linked to tumor progression, invasion, and drug …

[HTML][HTML] Recent progress on FAK inhibitors with dual targeting capabilities for cancer treatment

X Wu, J Wang, Q Liang, R Tong, J Huang… - Biomedicine & …, 2022 - Elsevier
Focal adhesion kinase (FAK, also known as PTK2) is a tyrosine kinase that regulates
integrin and growth factor signaling pathways and is involved in the migration, proliferation …

[HTML][HTML] Focal adhesion kinase: from biological functions to therapeutic strategies

X Tan, Y Yan, B Song, S Zhu, Q Mei, K Wu - Experimental Hematology & …, 2023 - Springer
Focal adhesion kinase (FAK), a nonreceptor cytoplasmic tyrosine kinase, is a vital
participant in primary cellular functions, such as proliferation, survival, migration, and …