Background Mutations in the cardiac sodium channel gene SCN5A cause Brugada
syndrome (BrS), an arrhythmic disorder that is a leading cause of sudden death and lacks …

Summary Background Brugada syndrome (BrS) is a cardiac channelopathy that can result in
sudden cardiac death (SCD). SCN5A is the most frequent gene linked to BrS, but the …

Brugada syndrome (BrS) is one of the major causes of sudden cardiac death in young
people, while the underlying mechanisms are not completely understood. Here, we …

Abstract The voltage‐gated Nav1. 5 channels mediate the fast Na+ current (I Na) in
cardiomyocytes initiating action potentials and cardiac contraction. Downregulation of I Na …

Background Among rare channelopathies BrS patients are at high risk of sudden cardiac
death (SCD). SCN5A mutations are found in a quarter of patients. Other rare gene mutations …

Abstract Background Brugada syndrome (BrS) is an inherited cardiac arrhythmogenic
disease that predisposes patients to sudden cardiac death. It is associated with mutations in …

Brugada syndrome (BrS) is an inherited autosomal dominant cardiac channelopathy.
Pathogenic rare mutations in the SCN5A gene, encoding the alpha-subunit of the voltage …

Brugada syndrome (BrS) is a complex genetic cardiac ion channel disease that causes a
high predisposition to sudden cardiac death. Considering that its heterogeneity in clinical …

SCN5A is abundant in heart and has a major role in I Na. Loss-of-function mutation in
SCN5A results in Brugada syndrome (BrS), which causes sudden death in adults. It remains …

Abstract Aims Brugada syndrome (BrS) is associated with a pronounced risk to develop
sudden cardiac death (SCD). Up to 21% of patients are related to mutations in SCN5A …