Pyruvate occupies a central metabolic node by virtue of its position at the crossroads of
glycolysis and the tricarboxylic acid (TCA) cycle and its production and fate being governed …

Pyruvate carboxylase (PC) is a mitochondrial enzyme that catalyzes the ATP-dependent
carboxylation of pyruvate to oxaloacetate (OAA), serving to replenish the tricarboxylic acid …

The central glycolytic and oxidative pathways and the ATP-producing mechanisms differ in
sane and malignant cells by their regulation and dynamics. Fast-growing, poorly …

Cancer cells exhibit an altered metabolism which is characterized by a preference for
aerobic glycolysis more than mitochondrial oxidation of pyruvate. This provides anabolic …

The extraction of energy and biosynthetic building blocks from fuel metabolism is a
fundamental requisite for life. Through the action of cellular enzymes, complex carbon …

Pyruvate is a keystone molecule critical for numerous aspects of eukaryotic and human
metabolism. Pyruvate is the end-product of glycolysis, is derived from additional sources in …

Simple Summary The characteristic metabolic hallmark of cancer cells is the massive
catabolism of glucose by glycolysis, even under aerobic conditions—the so-called Warburg …

Metabolic reprogramming in cancer supports the increased biosynthesis required for
unchecked proliferation. Increased glucose utilization is a defining feature of many cancers …

Tumor cells require a constant supply of macromolecular precursors, and interrupting this
supply has been proposed as a therapeutic strategy in cancer. Precursors for lipids, nucleic …

Stem and progenitor cells proliferate and give rise to other types of cells through
differentiation. Deregulation of this process can lead to many diseases including cancer …