The circuitry within the thalamus creates an intrinsic oscillatory unit whose function depends
critically on reciprocal synaptic connectivity between excitatory thalamocortical relay …

Thalamic oscillators contribute to both normal rhythms associated with sleep and anesthesia
and abnormal, hypersynchronous oscillations that manifest behaviorally as absence …

The absence epilepsies are characterized by recurrent episodes of loss of consciousness
associated with generalized spike-and-wave discharges, with an abrupt onset and offset, in …

Inhibitory connections between neurons of the thalamic reticular (RE) nucleus are thought to
help prevent spike-wave discharge (SWD), characteristic of generalized absence epilepsy …

Networks of interconnected inhibitory neurons, such as the thalamic reticular nucleus (TRN),
often regulate neural oscillations. Thalamic circuits generate sleep spindles and may …

Thalamic relay neurons have well-characterized dual firing modes: bursting and tonic
spiking. Studies in brain slices have led to a model in which rhythmic synchronized spiking …

The interplay between the intrinsic properties of thalamocortical (TC) neurons and synaptic
potentials was investigated in vivo, in decorticated and intact-cortex cats, as well as in …

Thalamocortical oscillations mediate both physiological and pathophysiological behaviors
including sleep and generalized absence epilepsy (GA). Reciprocal intrathalamic circuitry …

In humans with absence epilepsy, spike-and-wave discharges develop in the
thalamocortical system during quiet immobile wakefulness or drowsiness. The present study …

Behaviorally and pathologically relevant cortico-thalamo-cortical oscillations are driven by
diverse interacting cell-intrinsic and synaptic processes. However, the mechanism that gives …