DNA methylation profiling identifies a high effect genetic variant for lipoprotein (a) levels

GT Jones, J Marsman, B Bhat, VL Phillips… - Epigenetics, 2020 - Taylor & Francis
Changes in whole blood DNA methylation levels at several CpG sites have been associated
with circulating blood lipids, specifically high-density lipoprotein and triglycerides. This study …

[HTML][HTML] A genome-wide analysis of DNA methylation identifies a novel association signal for Lp(a) concentrations in the LPA promoter

S Coassin, N Hermann-Kleiter, M Haun, S Wahl… - Plos one, 2020 - journals.plos.org
Lipoprotein (a)[Lp (a)] is a major cardiovascular risk factor, which is largely genetically
determined by one major gene locus, the LPA gene. Many aspects of the transcriptional …

[HTML][HTML] Epigenome-wide association study (EWAS) on lipids: the Rotterdam Study

KVE Braun, K Dhana, PS de Vries, T Voortman… - Clinical …, 2017 - Springer
Background DNA methylation is a key epigenetic mechanism that is suggested to be
associated with blood lipid levels. We aimed to identify CpG sites at which DNA methylation …

DNA methylation variations at CETP and LPL gene promoter loci: new molecular biomarkers associated with blood lipid profile variability

SP Guay, D Brisson, B Lamarche, P Marceau, MC Vohl… - Atherosclerosis, 2013 - Elsevier
BACKGROUND: Recent findings suggest that DNA methylation, a well-known epigenetic
mechanism, is involved in high-density lipoprotein cholesterol (HDL-C) metabolism and …

DNA Methylation and High-Density Lipoprotein Functionality—Brief Report: The REGICOR Study (Registre Gironi del Cor)

S Sayols-Baixeras, A Hernáez, I Subirana… - … , and vascular biology, 2017 - Am Heart Assoc
Objective—The function of high-density lipoproteins (HDLs) may better reflect their
atheroprotective role, compared with HDL-cholesterol levels. The association between DNA …

Identification and validation of seven new loci showing differential DNA methylation related to serum lipid profile: an epigenome-wide approach. The REGICOR study

S Sayols-Baixeras, I Subirana… - Human molecular …, 2016 - academic.oup.com
Lipid traits (total, low-density and high-density lipoprotein cholesterol, and triglycerides) are
risk factors for cardiovascular disease. DNA methylation is not only an inherited but also …

[HTML][HTML] A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids

MA Jhun, M Mendelson, R Wilson, R Gondalia… - Nature …, 2021 - nature.com
Here we examine the association between DNA methylation in circulating leukocytes and
blood lipids in a multi-ethnic sample of 16,265 subjects. We identify 148, 35, and 4 novel …

Epigenetic patterns in blood associated with lipid traits predict incident coronary heart disease events and are enriched for results from genome-wide association …

ÅK Hedman, MM Mendelson, RE Marioni… - Circulation …, 2017 - Am Heart Assoc
Background—Genome-wide association studies have identified loci influencing circulating
lipid concentrations in humans; further information on novel contributing genes, pathways …

Epigenome-wide association study of fasting blood lipids in the genetics of lipid-lowering drugs and diet network study

MR Irvin, D Zhi, R Joehanes, M Mendelson… - Circulation, 2014 - Am Heart Assoc
Background—Genetic research regarding blood lipids has largely focused on DNA
sequence variation; few studies have explored epigenetic effects. Genome-wide surveys of …

Genetic variants modify the effect of age on APOE methylation in the Genetics of Lipid Lowering Drugs and Diet Network study

Y Ma, CE Smith, CQ Lai, MR Irvin, LD Parnell… - Aging cell, 2015 - Wiley Online Library
Although apolipoprotein E (APOE) variants are associated with age‐related diseases, the
underlying mechanism is unknown and DNA methylation may be a potential one. With …