Nuclear reprogramming to a pluripotent state by three approaches
S Yamanaka, HM Blau - Nature, 2010 - nature.com
The stable states of differentiated cells are now known to be controlled by dynamic
mechanisms that can easily be perturbed. An adult cell can therefore be reprogrammed …
mechanisms that can easily be perturbed. An adult cell can therefore be reprogrammed …
Nuclear reprogramming and pluripotency
K Hochedlinger, R Jaenisch - Nature, 2006 - nature.com
The cloning of mammals from differentiated donor cells has refuted the old dogma that
development is an irreversible process. It has demonstrated that the oocyte can …
development is an irreversible process. It has demonstrated that the oocyte can …
Nuclear reprogramming in cells
JB Gurdon, DA Melton - science, 2008 - science.org
Nuclear reprogramming describes a switch in gene expression of one kind of cell to that of
another unrelated cell type. Early studies in frog cloning provided some of the first …
another unrelated cell type. Early studies in frog cloning provided some of the first …
Somatic cell nuclear transfer
I Wilmut, N Beaujean, PA De Sousa, A Dinnyes… - Nature, 2002 - nature.com
Cloning by nuclear transfer from adult somatic cells is a remarkable demonstration of
developmental plasticity. When a nucleus is placed in oocyte cytoplasm, the changes in …
developmental plasticity. When a nucleus is placed in oocyte cytoplasm, the changes in …
Developmental reprogramming after chromosome transfer into mitotic mouse zygotes
D Egli, J Rosains, G Birkhoff, K Eggan - Nature, 2007 - nature.com
Until now, animal cloning and the production of embryonic stem cell lines by somatic cell
nuclear transfer have relied on introducing nuclei into meiotic oocytes. In contrast, attempts …
nuclear transfer have relied on introducing nuclei into meiotic oocytes. In contrast, attempts …
Mechanisms of nuclear reprogramming by eggs and oocytes: a deterministic process?
J Jullien, V Pasque, RP Halley-Stott… - … reviews Molecular cell …, 2011 - nature.com
Differentiated cells can be experimentally reprogrammed back to pluripotency by nuclear
transfer, cell fusion or induced pluripotent stem cell technology. Nuclear transfer and cell …
transfer, cell fusion or induced pluripotent stem cell technology. Nuclear transfer and cell …
Nuclear reprogramming and stem cell creation
JB Gurdon, JA Byrne… - Proceedings of the …, 2003 - National Acad Sciences
The transplantation of a somatic cell nucleus to an enucleated egg results in a major
reprogramming of gene expression and switch in cell fate. We review the efficiency of …
reprogramming of gene expression and switch in cell fate. We review the efficiency of …
Characterization of somatic cell nuclear reprogramming by oocytes in which a linker histone is required for pluripotency gene reactivation
J Jullien, C Åstrand, RP Halley-Stott… - Proceedings of the …, 2010 - National Acad Sciences
When transplanted into Xenopus oocytes, the nuclei of mammalian somatic cells are
reprogrammed to express stem cell genes such as Oct4, Nanog, and Sox2. We now …
reprogrammed to express stem cell genes such as Oct4, Nanog, and Sox2. We now …
Human therapeutic cloning
RP Lanza, JB Cibelli, MD West - Nature Medicine, 1999 - nature.com
Somatic cell nuclear'reprogramming'in livestock species is now routine in many laboratories.
Here, Robert Lanza, Jose Cibelli and Michael West discuss how these techniques may soon …
Here, Robert Lanza, Jose Cibelli and Michael West discuss how these techniques may soon …
Human oocytes reprogram somatic cells to a pluripotent state
S Noggle, HL Fung, A Gore, H Martinez, KC Satriani… - Nature, 2011 - nature.com
The exchange of the oocyte's genome with the genome of a somatic cell, followed by the
derivation of pluripotent stem cells, could enable the generation of specific cells affected in …
derivation of pluripotent stem cells, could enable the generation of specific cells affected in …