Exploring the role of antioxidants in sepsis-associated oxidative stress: a comprehensive review

DK Sahoo, D Wong, A Patani, B Paital… - Frontiers in Cellular …, 2024 - frontiersin.org
Sepsis is a potentially fatal condition characterized by organ dysfunction caused by an
imbalanced immune response to infection. Although an increased inflammatory response …

The interplay of oxidative stress and ROS scavenging: antioxidants as a therapeutic potential in sepsis

S Kumar, J Saxena, VK Srivastava, S Kaushik, H Singh… - Vaccines, 2022 - mdpi.com
Oxidative stress resulting from the disproportion of oxidants and antioxidants contributes to
both physiological and pathological conditions in sepsis. To combat this, the antioxidant …

Potential antioxidant multitherapy against complications occurring in sepsis

J Abelli, G Méndez-Valdés, F Gómez-Hevia… - Biomedicines, 2022 - mdpi.com
Septic shock currently represents one of the main causes of mortality in critical patient units
with an increase in its incidence in recent years, and it is also associated with a high burden …

The role of antioxidants in sepsis management: a review of therapeutic applications

H Üstündağ - Eurasian Journal of Molecular and Biochemical …, 2023 - dergipark.org.tr
Sepsis represents a life-threatening clinical condition characterized by a dysregulated host
response to infection leading to organ dysfunction. It affects approximately 49 million people …

Oxidative stress in sepsis: pathophysiological implications justifying antioxidant co-therapy

CA Prauchner - Burns, 2017 - Elsevier
Sepsis is one of the main causes of death among critically ill patients. Sepsis pathogenesis
includes infection by gram-negative and gram-positive bacteria, fungi, or both; exacerbated …

Sepsis: redox mechanisms and therapeutic opportunities

S Biswal, DG Remick - Antioxidants & Redox Signaling, 2007 - liebertpub.com
DESPITE ADVANCEMENTS IN THE treatment of critically ill patients, sepsis remains the
leading cause of death in the ICU—an estimated 175,000 deaths per year (2). The incidence …

Role of oxidative stress in experimental sepsis and multisystem organ dysfunction

E Crimi, V Sica, AS Slutsky, H Zhang… - Free radical …, 2006 - Taylor & Francis
Massive increase in radical species can lead to oxidative stress, promoting cell injury and
death. This review focuses on experimental evidence of oxidative stress in critical illnesses …

Impact of Treatment with Antioxidants as an Adjuvant to Standard Therapy in Patients with Septic Shock: Analysis of the Correlation between Cytokine Storm and …

I Pérez-Torres, A Aisa-Álvarez… - International Journal of …, 2023 - mdpi.com
Cellular homeostasis is lost or becomes dysfunctional during septic shock due to the
activation of the inflammatory response and the deregulation of oxidative stress. Antioxidant …

Role of oxidants in lung injury during sepsis

RF Guo, PA Ward - Antioxidants & redox signaling, 2007 - liebertpub.com
The role of oxidative stress has been well appreciated in the development of sepsis-induced
acute lung injury (ALI). Oxidative stress in sepsis-induced ALI is believed to be initiated by …

The sepsis induced defective aggravation of immune cells: a translational science underling chemico-biological interactions from altered bioenergetics and/or cellular …

WH Almalki - Molecular and cellular biochemistry, 2021 - Springer
Sepsis is described as a systemic immune response of the body to an infectious process that
might result in dysfunctional organs that may lead to death. In clinical practice, sepsis is …