Free radicals: relationship to human diseases and potential therapeutic applications

BL Zaric, MT Macvanin, ER Isenovic - The International Journal of …, 2023 - Elsevier
Reactive species are highly-reactive enzymatically, or non-enzymatically produced
compounds with important roles in physiological and pathophysiological cellular processes …

The chemistry of reactive oxygen species (ROS) revisited: outlining their role in biological macromolecules (DNA, lipids and proteins) and induced pathologies

CA Juan, JM Pérez de la Lastra, FJ Plou… - International journal of …, 2021 - mdpi.com
Living species are continuously subjected to all extrinsic forms of reactive oxidants and
others that are produced endogenously. There is extensive literature on the generation and …

From reactive species to disease development: Effect of oxidants and antioxidants on the cellular biomarkers

CM Curieses Andrés… - … of Biochemical and …, 2023 - Wiley Online Library
The influence of modern lifestyle, diet, exposure to chemicals such as phytosanitary
substances, together with sedentary lifestyles and lack of exercise play an important role in …

[PDF][PDF] Unraveling the biological roles of reactive oxygen species

MP Murphy, A Holmgren, NG Larsson, B Halliwell… - Cell metabolism, 2011 - cell.com
Reactive oxygen species are not only harmful agents that cause oxidative damage in
pathologies, they also have important roles as regulatory agents in a range of biological …

[PDF][PDF] Free radicals: From health to disease

A Santo, H Zhu, YR Li - React. Oxyg. Species, 2016 - researchgate.net
Over the past 40 years, there has been a tremendous amount of research on the dual role of
free radicals as both toxic and beneficial species. Free radicals are produced as by-products …

Free radicals and related reactive species as mediators of tissue injury and disease: implications for health

JP Kehrer, LO Klotz - Critical reviews in toxicology, 2015 - Taylor & Francis
A radical is any molecule that contains one or more unpaired electrons. Radicals are normal
products of many metabolic pathways. Some exist in a controlled (caged) form as they …

Free radicals: what they are and what they do

E Tvrdá, F Benko - Pathology, 2020 - Elsevier
Free radicals (FRs) have gained significant attention in the field of biology and medicine due
to their “double-edged sword roles” in numerous physiological processes as well as their …

Free radicals as mediators of tissue injury and disease

JP Kehrer - Critical reviews in toxicology, 1993 - Taylor & Francis
A radical is any molecule that contains one or more unpaired electrons. Radicals are
normally generated in many metabolic pathways. Some of these radicals can exist in a free …

[HTML][HTML] Role of free radicals and antioxidants in health and disease

SJS Flora - Cellular and Molecular Biology, 2007 - cellmolbiol.org
Over the past few decades, free radicals, highly reactive and thereby destructive molecules,
are known increasingly for their importance to human health and disease. Many common …

[PDF][PDF] Free radicals in health and diseases-a mini review

V Sivanandham - Pharmacologyonline, 2011 - researchgate.net
Free radicals and related species have attracted a great deal of attention in recent years.
They are mainly derived form oxygen (reactive oxygen species/ROS) and nitrogen (reactive …