The lack of appropriate experimental models often limits our ability to investigate the
establishment of infections in specific tissues. To reproduce the structural and spatial …

Many diseases necessitate the substitution of vaginal tissues. Current replacement
therapies are associated with many complications. In this study, we aimed to create …

A limitation in advancing the study of HIV-1 is the lack of a suitable small animal model
system that allows for HIV-1 infection to be monitored within human target epithelium …

Human tissue explants are a valuable tool to study the interactions between host and
infectious agents. They reliably mimic many important aspects of tissue cytoarchitecture and …

Globally, the most frequent route of HIV transmission is through sexual intercourse. In
women, sexual transmission of HIV involves cervical, vaginal, endometrial, and rectal …

Objective: The early steps of HIV entry into intact vaginal mucosa still need to be clarified.
Here we investigated how HIV translocated across the vaginal pluristratified epithelium …

Citation Merbah M, Introini A, Fitzgerald W, Grivel J‐C, Lisco A, Vanpouille C, Margolis L.
Cervico‐vaginal tissue ex vivo as a model to study early events in HIV‐1 infection. Am J …

Histocultures allow studying intercellular interactions within human tissues, and they can be
employed to model host-pathogen interactions under controlled laboratory conditions. Ex …

Abstract Three-dimensional (3D) human tissue models/microphysiological systems (eg,
organs-on-chips, organoids, and tissue explants) model HIV and related comorbidities and …

Healthy vaginal epithelium is essential for normal reproductive functions and protects
against infectious diseases. Here, we present a protocol for developing mouse vaginal …