In vitro study of licorice on IL-1β-induced chondrocytes and in silico approach for osteoarthritis
Osteoarthritis (OA) is a common degenerative joint disorder that affects joint function,
mobility, and pain. The release of proinflammatory cytokines stimulates matrix …
mobility, and pain. The release of proinflammatory cytokines stimulates matrix …
Isoliquiritigenin blunts osteoarthritis by inhibition of bone resorption and angiogenesis in subchondral bone
B Ji, Z Zhang, W Guo, H Ma, B Xu, W Mu, A Amat… - Scientific Reports, 2018 - nature.com
Isoliquiritigenin (ISL), a natural flavonoid extracted from licorice, has been demonstrated to
exert attenuation of osteoclastogenesis and anti-angiogenesis activity in a wide variety of …
exert attenuation of osteoclastogenesis and anti-angiogenesis activity in a wide variety of …
Glycyrrhizin inhibits osteoarthritis development through suppressing the PI3K/AKT/NF-κB signaling pathway in vivo and in vitro
RH Jiang, JJ Xu, DC Zhu, JF Li, CX Zhang, N Lin… - Food & function, 2020 - pubs.rsc.org
Osteoarthritis (OA) is a serious and frequently occurring disease in the elderly, characterized
by cartilage degeneration and proliferation of bone structure. Glycyrrhizin, a compound …
by cartilage degeneration and proliferation of bone structure. Glycyrrhizin, a compound …
Exploring the pharmacological mechanism of Glycyrrhiza uralensis against KOA through integrating network pharmacology and experimental assessment
J Xu, Q Sun, M Qiu, Y Wu, L Cheng… - Journal of Cellular …, 2024 - Wiley Online Library
Knee osteoarthritis (KOA), a major health and economic problem facing older adults
worldwide, is a degenerative joint disease. Glycyrrhiza uralensis Fisch.(GC) plays an …
worldwide, is a degenerative joint disease. Glycyrrhiza uralensis Fisch.(GC) plays an …
[HTML][HTML] Quercetin-3-O-β-D-glucuronide attenuates osteoarthritis by inhibiting cartilage extracellular matrix degradation and inflammation
H Mao, Y Feng, J Feng, Y Yusufu, M Sun… - Journal of Orthopaedic …, 2024 - Elsevier
Objective Osteoarthritis (OA) is a chronic degenerative joint disease characterized by
cartilage damage. In order to find a safer and more effective drug to treat OA, we …
cartilage damage. In order to find a safer and more effective drug to treat OA, we …
Network pharmacology and molecular docking to elucidate the potential mechanism of ligusticum chuanxiong against osteoarthritis
C Xiang, Y Liao, Z Chen, B Xiao, Z Zhao, A Li… - Frontiers in …, 2022 - frontiersin.org
Background: Osteoarthritis (OA) is a degenerative disease which serious affects patients.
Ligusticum chuanxiong (CX) has been shown to have a certain curative effect on …
Ligusticum chuanxiong (CX) has been shown to have a certain curative effect on …
[HTML][HTML] Investigating the protective effect of tanshinone IIA against chondrocyte dedifferentiation: a combined molecular biology and network pharmacology approach
Y Zhang, L Sun, X Liu, D Zhu, J Dang… - Annals of Translational …, 2021 - ncbi.nlm.nih.gov
Background Osteoarthritis (OA) is a common degenerative disease with multifactorial
etiology. The dedifferentiation of chondrocytes can accelerate the progress of OA …
etiology. The dedifferentiation of chondrocytes can accelerate the progress of OA …
Elucidation of the Underlying Mechanism of Gujian Oral Liquid Acting on Osteoarthritis through Network Pharmacology, Molecular Docking, and Experiment
C Wu, Q Ge, Z Shi, J Ying, Q Sun… - BioMed Research …, 2022 - Wiley Online Library
Gujian oral liquid (GJ), a traditional herbal formula in China, has been widely used to treat
patients with osteoarthritis (OA). Nevertheless, the active component and potential …
patients with osteoarthritis (OA). Nevertheless, the active component and potential …
Potential therapeutic mechanism of radix angelicae biseratae and dipsaci radix herb pair against osteoarthritis: based on network pharmacology and molecular …
Y Xi, T Zhao, M Shi, X Zhang, Y Bao… - Evidence‐Based …, 2023 - Wiley Online Library
Background. A major contributor to older disability is osteoarthritis. Radix Angelicae
Biseratae (known as Duhuo in China, DH, the dried rhizome of Angelica pubescens) and …
Biseratae (known as Duhuo in China, DH, the dried rhizome of Angelica pubescens) and …
Liquiritin reduces chondrocyte apoptosis through P53/PUMA signaling pathway to alleviate osteoarthritis
M Qiu, L Cheng, J Xu, M Jin, W Yuan, Q Ge, K Zou… - Life Sciences, 2024 - Elsevier
Aims The main pathological features of osteoarthritis (OA) include the degeneration of
articular cartilage and a decrease in matrix synthesis. Chondrocytes, which contribute to …
articular cartilage and a decrease in matrix synthesis. Chondrocytes, which contribute to …