HIV peptidome-wide association study reveals patient-specific epitope repertoires associated with HIV control
J Arora, PJ McLaren, N Chaturvedi… - Proceedings of the …, 2019 - National Acad Sciences
Genetic variation in the peptide-binding groove of the highly polymorphic HLA class I
molecules has repeatedly been associated with HIV-1 control and progression to AIDS …
molecules has repeatedly been associated with HIV-1 control and progression to AIDS …
Broad and Gag-biased HIV-1 epitope repertoires are associated with lower viral loads
M Rolland, D Heckerman, W Deng, CM Rousseau… - PloS one, 2008 - journals.plos.org
Background HLA class-I alleles differ in their ability to control HIV replication through cell-
mediated immune responses. No consistent associations have been found between the …
mediated immune responses. No consistent associations have been found between the …
HLA heterozygote advantage against HIV-1 is driven by quantitative and qualitative differences in HLA allele-specific peptide presentation
Pathogen-mediated balancing selection is regarded as a key driver of host immunogenetic
diversity. A hallmark for balancing selection in humans is the heterozygote advantage at …
diversity. A hallmark for balancing selection in humans is the heterozygote advantage at …
Identification of immunodominant HIV-1 epitopes presented by HLA-C* 12: 02, a protective allele, using an immunopeptidomics approach
T Chikata, W Paes, T Akahoshi, T Partridge… - Journal of …, 2019 - Am Soc Microbiol
Despite the fact that the cell surface expression level of HLA-C on both uninfected and HIV-
infected cells is lower than those of HLA-A and-B, increasing evidence suggests an …
infected cells is lower than those of HLA-A and-B, increasing evidence suggests an …
HLA-B57 micropolymorphism defines the sequence and conformational breadth of the immunopeptidome
Immunophenotypic differences between closely related human leukocyte antigen (HLA)
alleles have been associated with divergent clinical outcomes in infection, autoimmunity …
alleles have been associated with divergent clinical outcomes in infection, autoimmunity …
Adaptive interactions between HLA and HIV-1: highly divergent selection imposed by HLA class I molecules with common supertype motifs
M John, D Heckerman, I James, LP Park… - The Journal of …, 2010 - journals.aai.org
Abstract Currently, 1.1 million individuals in the United States are living with HIV-1 infection.
Although this is a relatively small proportion of the global pandemic, the remarkable mix of …
Although this is a relatively small proportion of the global pandemic, the remarkable mix of …
HLA-B molecules target more conserved regions of the HIV-1 proteome
AIF Costa, X Rao, E LeChenadec, D van Baarle… - Aids, 2010 - journals.lww.com
Background: HLA-B alleles of HIV-infected individuals have been shown to have a major
impact on their rate of progression toward AIDS, and the T-cell responses they restrict are …
impact on their rate of progression toward AIDS, and the T-cell responses they restrict are …
Impact of micropolymorphism outside the peptide binding groove in the clinically relevant allele HLA-C* 14 on T cell responses in HIV-1 infection
T Chikata, W Paes, N Kuse, T Partridge… - Journal of …, 2022 - Am Soc Microbiol
There is increasing evidence for the importance of human leukocyte antigen C (HLA-C)-
restricted CD8+ T cells in HIV-1 control, but these responses are relatively poorly …
restricted CD8+ T cells in HIV-1 control, but these responses are relatively poorly …
The major genetic determinants of HIV-1 control affect HLA class I peptide presentation
International HIV Controllers Study - Science, 2010 - science.org
Infectious and inflammatory diseases have repeatedly shown strong genetic associations
within the major histocompatibility complex (MHC); however, the basis for these associations …
within the major histocompatibility complex (MHC); however, the basis for these associations …
Impact of HLA class I functional divergence on HIV control
M Viard, C O'hUigin, Y Yuki, AA Bashirova, DR Collins… - Science, 2024 - science.org
Heterozygosity of Human leukocyte antigen (HLA) class I genes is linked to beneficial
outcomes after HIV infection, presumably through greater breadth of HIV epitope …
outcomes after HIV infection, presumably through greater breadth of HIV epitope …