Clathrin-mediated endocytosis (CME) is the main mechanism by which mammalian cells
control their cell surface proteome. Proper operation of the pivotal CME cargo adaptor AP2 …

Summary Adaptor protein 2 (AP2) is a major constituent of clathrin-coated pits (CCPs).
Whether it is essential for all forms of clathrin-mediated endocytosis (CME) in mammalian …

The critical initiation phase of clathrin-mediated endocytosis (CME) determines where and
when endocytosis occurs. Heterotetrameric adaptor protein 2 (AP2) complexes, which …

Besides AP-2 and clathrin triskelia, clathrin coat inception depends on a group of early-
arriving proteins including Fcho1/2 and Eps15/R. Using genome-edited cells, we described …

Clathrin-coated vesicles form by rapid assembly of discrete coat constituents into a cargo-
sorting lattice. How the sequential phases of coat construction are choreographed is …

Clathrin-mediated endocytosis, the major pathway for ligand internalization into eukaryotic
cells, is thought to be initiated by the clustering of clathrin and adaptors around receptors …

Clathrin-mediated endocytosis (CME) is a central trafficking pathway in eukaryotic cells
regulated by phosphoinositides. The plasma membrane phosphatidylinositol-4, 5 …

Clathrin-mediated endocytosis (CME) is crucial for modulating the protein composition of a
cell's plasma membrane. Clathrin forms a cage-like, polyhedral outer scaffold around a …

The AP2 adaptor complex (α, β2, σ2, and μ2 subunits) crosslinks the endocytic clathrin
scaffold to PtdIns4, 5P 2-containing membranes and transmembrane protein cargo. In the" …

Clathrin-mediated endocytosis (CME) is vital for the internalization of most cell-surface
proteins. In CME, plasma membrane–binding clathrin adaptors recruit and polymerize …