P2RY12-inhibitors reduce cancer-associated thrombosis and tumor growth in pancreatic cancers

AL Palacios-Acedo, S Mezouar, D Mège… - Frontiers in …, 2021 - frontiersin.org
Platelet function can be modified by cancer cells to support tumor growth, causing
alterations in the delicate hemostatic equilibrium. Cancer-cell and platelet interactions are …

Antiplatelet drug ticagrelor enhances chemotherapeutic efficacy by targeting the novel P2Y12-AKT pathway in pancreatic cancer cells

O Elaskalani, A Domenchini, NB Abdol Razak… - Cancers, 2020 - mdpi.com
Background: Extensive research has reported that extracellular ADP in the tumour
microenvironment can stimulate platelets through interaction with the platelet receptor …

Platelet and cancer-cell interactions modulate cancer-associated thrombosis risk in different cancer types

AL Palacios-Acedo, M Langiu, L Crescence, D Mège… - Cancers, 2022 - mdpi.com
Simple Summary Cancer-associated thrombosis is the first cause of death in cancer after
cancer-progression itself; however, thrombotic risk is not the same in all cancer types. Here …

P2Y12 Receptors in Tumorigenesis and Metastasis

P Ballerini, M Dovizio, A Bruno, S Tacconelli… - Frontiers in …, 2018 - frontiersin.org
Platelets, beyond their role in hemostasis and thrombosis, may sustain tumorigenesis and
metastasis. These effects may occur via direct interaction of platelets with cancer and …

The role of coagulation and platelets in colon cancer-associated thrombosis

A Mitrugno, S Tassi Yunga, JL Sylman… - … of Physiology-Cell …, 2019 - journals.physiology.org
Cancer-associated thrombosis is a common first presenting sign of malignancy and is
currently the second leading cause of death in cancer patients after their malignancy …

The TICONC (Ticagrelor-Oncology) Study: Implications of P2Y12 Inhibition for Metastasis and Cancer-Associated Thrombosis

JR Wright, M Chauhan, C Shah, A Ring, AL Thomas… - Cardio Oncology, 2020 - jacc.org
Background In cancer, platelets may facilitate metastatic spread by a number of mechanisms
as well as contribute to thrombotic complications. Ticagrelor, a platelet antagonist-that …

Targeting tyrosine phosphatases by 3-bromopyruvate overcomes hyperactivation of platelets from gastrointestinal cancer patients

AVS Faria, SS Andrade, AN Reijm… - Journal of clinical …, 2019 - mdpi.com
Venous thromboembolism (VTE) is one of the most common causes of cancer related
mortality. It has been speculated that hypercoagulation in cancer patients is triggered by …

[HTML][HTML] The provocative roles of platelets in liver disease and cancer

PK Marie, NW Fowlkes, V Afshar-Kharghan… - Frontiers in …, 2021 - ncbi.nlm.nih.gov
Both platelets and the liver play important roles in the processes of coagulation and innate
immunity. Platelet responses at the site of an injury are rapid; their immediate activation and …

The provocative roles of platelets in liver disease and cancer

P Kanikarla Marie, NW Fowlkes… - Frontiers in …, 2021 - frontiersin.org
Both platelets and the liver play important roles in the processes of coagulation and innate
immunity. Platelet responses at the site of an injury are rapid; their immediate activation and …

Platelets: the point of interconnection among cancer, inflammation and cardiovascular diseases

M Camilli, G Iannaccone, G La Vecchia… - Expert review of …, 2021 - Taylor & Francis
Introduction The association between thrombosis, cancer and inflammation is well-
established. Platelets play a major role in atherosclerosis, inflammation and immune …