P2RY12-inhibitors reduce cancer-associated thrombosis and tumor growth in pancreatic cancers
AL Palacios-Acedo, S Mezouar, D Mège… - Frontiers in …, 2021 - frontiersin.org
Platelet function can be modified by cancer cells to support tumor growth, causing
alterations in the delicate hemostatic equilibrium. Cancer-cell and platelet interactions are …
alterations in the delicate hemostatic equilibrium. Cancer-cell and platelet interactions are …
Antiplatelet drug ticagrelor enhances chemotherapeutic efficacy by targeting the novel P2Y12-AKT pathway in pancreatic cancer cells
O Elaskalani, A Domenchini, NB Abdol Razak… - Cancers, 2020 - mdpi.com
Background: Extensive research has reported that extracellular ADP in the tumour
microenvironment can stimulate platelets through interaction with the platelet receptor …
microenvironment can stimulate platelets through interaction with the platelet receptor …
Platelet and cancer-cell interactions modulate cancer-associated thrombosis risk in different cancer types
AL Palacios-Acedo, M Langiu, L Crescence, D Mège… - Cancers, 2022 - mdpi.com
Simple Summary Cancer-associated thrombosis is the first cause of death in cancer after
cancer-progression itself; however, thrombotic risk is not the same in all cancer types. Here …
cancer-progression itself; however, thrombotic risk is not the same in all cancer types. Here …
P2Y12 Receptors in Tumorigenesis and Metastasis
Platelets, beyond their role in hemostasis and thrombosis, may sustain tumorigenesis and
metastasis. These effects may occur via direct interaction of platelets with cancer and …
metastasis. These effects may occur via direct interaction of platelets with cancer and …
The role of coagulation and platelets in colon cancer-associated thrombosis
Cancer-associated thrombosis is a common first presenting sign of malignancy and is
currently the second leading cause of death in cancer patients after their malignancy …
currently the second leading cause of death in cancer patients after their malignancy …
The TICONC (Ticagrelor-Oncology) Study: Implications of P2Y12 Inhibition for Metastasis and Cancer-Associated Thrombosis
JR Wright, M Chauhan, C Shah, A Ring, AL Thomas… - Cardio Oncology, 2020 - jacc.org
Background In cancer, platelets may facilitate metastatic spread by a number of mechanisms
as well as contribute to thrombotic complications. Ticagrelor, a platelet antagonist-that …
as well as contribute to thrombotic complications. Ticagrelor, a platelet antagonist-that …
Targeting tyrosine phosphatases by 3-bromopyruvate overcomes hyperactivation of platelets from gastrointestinal cancer patients
AVS Faria, SS Andrade, AN Reijm… - Journal of clinical …, 2019 - mdpi.com
Venous thromboembolism (VTE) is one of the most common causes of cancer related
mortality. It has been speculated that hypercoagulation in cancer patients is triggered by …
mortality. It has been speculated that hypercoagulation in cancer patients is triggered by …
[HTML][HTML] The provocative roles of platelets in liver disease and cancer
PK Marie, NW Fowlkes, V Afshar-Kharghan… - Frontiers in …, 2021 - ncbi.nlm.nih.gov
Both platelets and the liver play important roles in the processes of coagulation and innate
immunity. Platelet responses at the site of an injury are rapid; their immediate activation and …
immunity. Platelet responses at the site of an injury are rapid; their immediate activation and …
The provocative roles of platelets in liver disease and cancer
P Kanikarla Marie, NW Fowlkes… - Frontiers in …, 2021 - frontiersin.org
Both platelets and the liver play important roles in the processes of coagulation and innate
immunity. Platelet responses at the site of an injury are rapid; their immediate activation and …
immunity. Platelet responses at the site of an injury are rapid; their immediate activation and …
Platelets: the point of interconnection among cancer, inflammation and cardiovascular diseases
M Camilli, G Iannaccone, G La Vecchia… - Expert review of …, 2021 - Taylor & Francis
Introduction The association between thrombosis, cancer and inflammation is well-
established. Platelets play a major role in atherosclerosis, inflammation and immune …
established. Platelets play a major role in atherosclerosis, inflammation and immune …