The proper accumulation and maintenance of stem cells is critical for organ development
and homeostasis. The Notch signaling pathway maintains stem cells in diverse organisms …

Coupling of stem/progenitor cell proliferation and differentiation to organismal physiological
demands ensures the proper growth and homeostasis of tissues. However, in vivo …

Adult C. elegans germline stem cells (GSCs) and mouse embryonic stem cells (mESCs)
exhibit a non-canonical cell cycle structure with an abbreviated G1 phase and phase …

A stem cell's immediate microenvironment creates an essential “niche” to maintain stem cell
self-renewal. Many niches and their intercellular signaling pathways are known, but for the …

Notch signaling regulates stem cells across animal phylogeny. C. elegans Notch signaling
activates transcription of two genes, lst-1 and sygl-1, that encode potent regulators of …

The Caenorhabditis elegans germline is an excellent model for studying the regulation of a
pool of stem cells and progression of cells from a stem cell state to a differentiated state. At …

Germline stem cell differentiation in Caenorhabditis elegans is controlled by glp-1 Notch
signaling. Cell fate regulator GLD-1 is sufficient to induce meiotic entry and expressed at a …

In the Caenorhabditis elegans germline, proliferation is induced by Notch-type signaling.
Entry of germ cells into meiosis is triggered by activity of the GLD-1 and GLD-2 pathways …

Coordination of the cell cycle with developmental events is crucial for generation of tissues
during development and their maintenance in adults. Defects in that coordination can shift …

Communication between the soma and germline optimizes germ cell fate programs. Notch
receptors are key determinants of germ cell fate but how somatic signals direct Notch …