Hypomethylating agents and chemotherapy in MDS

L Adès, V Santini - Best Practice & Research Clinical Haematology, 2013 - Elsevier
Until recently, the treatment of higher risk myelodysplastic syndrome was based on [1]
Intensive chemotherapy using anthracycline–AraC combinations, leading to a lower …

The euphoria of hypomethylating agents in MDS and AML: is it justified?

MA Sekeres - Best Practice & Research Clinical Haematology, 2013 - Elsevier
While it is logical to use hypomethylating agents to treat patients with myelodysplastic
syndromes (MDS) and acute myeloid leukemia (AML), trial results with azacitidine and …

Choosing a hypomethylating agent in MDS: does gender matter?

M Duchmann, R Itzykson - Leukemia & Lymphoma, 2017 - Taylor & Francis
Hypomethylating agents (HMA) are the first line treatment of higher-risk myelodysplastic
syndromes (MDS) ineligible for bone marrow transplant. Azacitidine (5-azacytine, AZA) …

Maintenance Treatment with Azacytidine for Patients with High Risk Myelodysplastic Syndromes or Acute Myeloid Leukaemia in Complete Remission after Intensive …

M Grövdal, R Khan, A Aggerholm, P Antunovic… - Blood, 2007 - Elsevier
Patients with high-risk myelodysplastic syndromes (MDS) or acute myeloid leukaemia (AML)
secondary to MDS may reach complete remission (CR) following intensive chemotherapy …

Treatment of higher-risk myelodysplastic syndromes after failure of hypomethylating agents

RS Komrokji - Clinical Lymphoma Myeloma and Leukemia, 2015 - Elsevier
Hypomethylating agents (HMAs) are the standard of care for higher-risk myelodysplastic
syndrome (MDS) patients in whom azacitidine was the only treatment to demonstrate an …

[HTML][HTML] Efficacy of Hypo-methylating agents in the treatment of myelodysplastic syndromes: a systematic review and meta-analysis of randomized controlled trials

A Kumar, AF List, R Mhaskar, B Djulbegovic - Blood, 2008 - Elsevier
Background: With the FDA approval of two hypomethylating agents (HA) for the treatment of
myelodysplastic syndromes (MDS), both azacitidine (AZA-C) and decitabine have shown …

Clinical impact of hypomethylating agents in the treatment of myelodysplastic syndromes

C Finelli, MY Follo, M Stanzani, S Parisi… - Current …, 2016 - ingentaconnect.com
Myelodysplastic syndromes (MDS) are a heterogeneous group of hematologic diseases,
mainly affecting the elderly, characterized by unilinear or multilinear peripheral cytopenia …

A call for action: increasing enrollment of untreated patients with higher‐risk myelodysplastic syndromes in first‐line clinical trials

AM Zeidan, M Stahl, MA Sekeres, DP Steensma… - Cancer, 2017 - Wiley Online Library
Hypomethylating agents (HMAs) have changed the landscape of the management of
patients with higher‐risk myelodysplastic syndromes (HR‐MDS). HMAs have improved …

How I treat MDS after hypomethylating agent failure

V Santini - Blood, The Journal of the American Society of …, 2019 - ashpublications.org
Hypomethylating agents (HMA) azacitidine and decitabine are standard of care for
myelodysplastic syndrome (MDS). Response to these agents occurs in∼ 50% of treated …

Hypomethylating agent combination strategies in myelodysplastic syndromes: hopes and shortcomings

B Ball, A Zeidan, SD Gore, T Prebet - Leukemia & lymphoma, 2017 - Taylor & Francis
The hypomethylating agents (HMA) azacitidine and decitabine are both approved by the
FDA for the treatment of myelodysplastic syndromes (MDS). Although heralded as a …