The nonobese diabetic mouse spontaneously develops an autoimmune, T-cell-mediated
type 1 diabetes (T1D). Common and rare alleles both within a diabetogenic major …

Type I diabetes has resisted direct genetic analysis in humans but two excellent models of
disease in rodents provide a more readily manipulated alternative for study. These rodent …

T1DM (Type I diabetes mellitus) results from selective destruction of the insulin-producing β-
cells of the pancreas by the immune system, and is characterized by hyperglycaemia and …

What are the common features that make studies of these various models so compelling?
And what do the features distinguishing the various models tell us about the human disease …

The nonobese diabetic (NOD) mouse represents probably the best spontaneous model for a
human autoimmune disease. It has provided not only essential information on type 1 …

Non-obese diabetic (NOD) mice are an excellent model of T-cell mediated autoimmune
insulin-dependent diabetes in humans. Recent studies in NOD mice have shown that this …

Type 1 diabetes (T1D) in both humans and nonobese diabetic (NOD) mice is a T‐cell‐
mediated autoimmune disease in which the insulin‐producing pancreatic islet β‐cells are …

There are well over 300 inbred mouse strains extant world-wide. Of these, only one, the
nonobese diabetic (NOD) mouse, initially expected to be a normoglycemic strain [1] …

Susceptibility to IDDM is strongly associated with major histocompatibility complex (MHC)
class II genotypes. Nonobese diabetic (NOD) mice develop a similar autoimmune diabetes …

The identification of causative genes for the autoimmune disease type 1 diabetes (T1D) in
humans and candidate genes in the NOD mouse has made significant progress in recent …