Tissue injury initiates an inflammatory response through the actions of immunostimulatory
molecules referred to as damage-associated molecular patterns (DAMPs). DAMPs …

The response to exogenous pathogens leads to activation of innate immunity through the
release of pathogen-associated molecular patterns (PAMPs) and their binding to pattern …

It is evident that components of the extracellular matrix (ECM) act as danger-associated
molecular patterns (DAMPs) through direct interactions with pattern recognition receptors …

Extracellular matrix (ECM) components, commonly thought to function purely as structural
elements are now demonstrated to act as signaling molecules. With the identification of …

Dendritic cells and macrophages are critical early initiators of innate immunity in the kidney
and orchestrate inflammation subsequent to ischemia-reperfusion injury. They are the most …

Damage-associated molecular patterns (DAMPs) include endogenous intracellular
molecules released by activated or necrotic cells and extracellular matrix (ECM) molecules …

Our body handles tissue damage by activating the immune system in response to
intracellular molecules released by injured tissues [damage-associated molecular patterns …

In reply to internal or external danger stimuli, the body orchestrates an inflammatory
response. The endogenous triggers of this process are the damage-associated molecular …

Sepsis refers to the deleterious and non-resolving systemic inflammatory response of the
host to microbial infection and is the leading cause of death in intensive care units. The …

Why does renal inflammation appear among many of the so-called noninflammatory kidney
diseases? Toll-like receptor research provides a surprising answer because activation of the …