The pancreatic islets are composed of discrete hormone-producing cells that orchestrate
systemic glucose homeostasis. Here we identify subsets of beta cells using a single-cell …

Ductal structures of the adult pancreas contain stem cells that differentiate into islets of
Langerhans. Here, we grew pancreatic ductal epithelial cells isolated from prediabetic adult …

Human pancreatic islets of Langerhans contain five distinct endocrine cell types, each
producing a characteristic hormone. The dysfunction or loss of the insulin-producing β cells …

Human pancreatic islets containing insulin-secreting β-cells are notoriously heterogeneous
in cell composition. Since β-cell failure is the root cause of diabetes, understanding this …

Despite advances in the differentiation of insulin-producing cells from human embryonic
stem cells, the generation of mature functional β cells in vitro has remained elusive. To …

Pancreatic islet cells are critical for maintaining normal blood glucose levels, and their
malfunction underlies diabetes development and progression. We used single-cell RNA …

In vitro differentiation of human stem cells can produce pancreatic β-cells; the loss of this
insulin-secreting cell type underlies type 1 diabetes. Here, as a step towards understanding …

Most research on human pancreatic islets is conducted on samples obtained from
normoglycaemic or diseased brain-dead donors and thus cannot accurately describe the …

Replacing missing insulin-producing β cells to treat diabetes is a major challenge for
regenerative medicine. A better understanding of β-cell embryogenesis and regeneration in …

Abstract Objective Islets of Langerhans contain heterogeneous populations of insulin-
producing β-cells. Surface markers and respective antibodies for isolation, tracking, and …