Macrophage ABCA5 deficiency influences cellular cholesterol efflux and increases susceptibility to atherosclerosis in female LDLr knockout mice
D Ye, I Meurs, M Ohigashi, L Calpe-Berdiel… - Biochemical and …, 2010 - Elsevier
OBJECTIVES: To determine the role of macrophage ATP-binding cassette transporter A5
(ABCA5) in cellular cholesterol homeostasis and atherosclerotic lesion development …
(ABCA5) in cellular cholesterol homeostasis and atherosclerotic lesion development …
Macrophage ATP-binding cassette transporter A1 overexpression inhibits atherosclerotic lesion progression in low-density lipoprotein receptor knockout mice
M Van Eck, RR Singaraja, D Ye… - … , and vascular biology, 2006 - Am Heart Assoc
Background—ATP-binding cassette transporter A1 (ABCA1) is a key regulator of cellular
cholesterol and phospholipid transport. Previously, we have shown that inactivation of …
cholesterol and phospholipid transport. Previously, we have shown that inactivation of …
[HTML][HTML] Macrophage ABCA2 deletion modulates intracellular cholesterol deposition, affects macrophage apoptosis, and decreases early atherosclerosis in LDL …
L Calpe-Berdiel, Y Zhao, M de Graauw, D Ye… - Atherosclerosis, 2012 - Elsevier
OBJECTIVE: The ABCA2 transporter shares high structural homology to ABCA1, which is
crucial for the removal of excess cholesterol from macrophages and, by extension, in …
crucial for the removal of excess cholesterol from macrophages and, by extension, in …
In vivo reverse cholesterol transport from macrophages lacking ABCA1 expression is impaired
MD Wang, V Franklin, YL Marcel - Arteriosclerosis, thrombosis, and …, 2007 - Am Heart Assoc
Background—ATP-binding cassette transporter A1 (ABCA1) is a key mediator of cholesterol
efflux to apoA-I in cholesterol loaded macrophages, a first step of reverse cholesterol …
efflux to apoA-I in cholesterol loaded macrophages, a first step of reverse cholesterol …
[HTML][HTML] Increased ABCA1 activity protects against atherosclerosis
C Fievet, G Castro, ER James… - The Journal of …, 2002 - Am Soc Clin Investig
The ABC transporter ABCA1 plays a key role in the first steps of the reverse cholesterol
transport pathway by mediating lipid efflux from macrophages. Previously, it was …
transport pathway by mediating lipid efflux from macrophages. Previously, it was …
Specific loss of ABCA1 (ATP-binding cassette transporter A1) suppresses TCR (T-cell receptor) signaling and provides protection against atherosclerosis
Y Zhao, L Zhang, L Liu, X Zhou, F Ding… - … and Vascular Biology, 2022 - Am Heart Assoc
Background: ABCA1 (ATP-binding cassette transporter A1) mediates cholesterol efflux to
apo AI to maintain cellular cholesterol homeostasis. The current study aims to investigate …
apo AI to maintain cellular cholesterol homeostasis. The current study aims to investigate …
ABCA8 regulates cholesterol efflux and high-density lipoprotein cholesterol levels
L Trigueros-Motos, JC van Capelleveen… - … , and vascular biology, 2017 - Am Heart Assoc
Objective—High-density lipoproteins (HDL) are considered to protect against
atherosclerosis in part by facilitating the removal of cholesterol from peripheral tissues …
atherosclerosis in part by facilitating the removal of cholesterol from peripheral tissues …
Effects of deletion of macrophage ABCA7 on lipid metabolism and the development of atherosclerosis in the presence and absence of ABCA1
I Meurs, L Calpe-Berdiel, KLL Habets, Y Zhao… - PloS one, 2012 - journals.plos.org
ABCA7, a close relative of ABCA1 which facilitates cholesterol efflux to lipid-poor
apoproteins, has been implicated in macrophage lipid efflux and clearance of apoptotic cells …
apoproteins, has been implicated in macrophage lipid efflux and clearance of apoptotic cells …
Increased Cholesterol Deposition, Expression of Scavenger Receptors, and Response to Chemotactic Factors in Abca1-Deficient Macrophages
OL Francone, L Royer, G Boucher… - … , and vascular biology, 2005 - Am Heart Assoc
Objective—Studies in bone marrow transplanted from ATP-binding cassette transporter A1
(ABCA1)–deficient mice into normal mice provides direct evidence that the absence of …
(ABCA1)–deficient mice into normal mice provides direct evidence that the absence of …
Leukocyte ABCA1 remains atheroprotective in splenectomized LDL receptor knockout mice
B Lammers, Y Zhao, AC Foks, RB Hildebrand… - PLoS …, 2012 - journals.plos.org
Aim ATP-binding cassette transporter A1 (ABCA1) is an important mediator of macrophage
cholesterol efflux. It mediates the efflux of cellular cholesterol to lipid-poor apolipoprotein AI …
cholesterol efflux. It mediates the efflux of cellular cholesterol to lipid-poor apolipoprotein AI …