OBJECTIVE Kidney disease manifests clinically as elevated albumin excretion rate (AER),
impaired glomerular filtration rate (GFR), or both, and is a cause of substantial morbidity and …

Background An impaired glomerular filtration rate (GFR) leads to end-stage renal disease
and increases the risks of cardiovascular disease and death. Persons with type 1 diabetes …

OBJECTIVE This multicenter study examined the impact of albumin excretion rate (AER) on
the course of estimated glomerular filtration rate (eGFR) and the incidence of sustained …

Aims/hypothesis We conducted an analysis of data collected during the Veterans Affairs
Diabetes Trial (VADT) and the follow-up study (VADT-F) to determine whether intensive …

Background Aggressive glycemic control has been hypothesized to prevent renal disease in
patients with type 2 diabetes mellitus. A systematic review was conducted to summarize the …

The effect of intensive glucose control on major kidney outcomes in type 2 diabetes remains
unclear. To study this, the ADVANCE trial randomly assigned 11,140 participants to an …

OBJECTIVE The Action in Diabetes and Vascular Disease: Preterax and Diamicron MR
Controlled Evaluation (ADVANCE) trial reported that intensive glucose control prevents end …

OBJECTIVE In type 1 diabetes (T1D), the course of microalbuminuria is unpredictable and
timing of glomerular filtration rate (GFR) loss is uncertain. Thus, there is a need to identify the …

Background Microalbuminuria is a common diagnosis in the clinical care of patients with
type 1 diabetes mellitus. Long-term outcomes after the development of microalbuminuria are …

Background Intensive diabetes treatment reduces the risk of developing albuminuria in
individuals with type 1 diabetes. Effects on the long-term clinical course of kidney disease …