Purine nucleotide degradation refers to a regulated series of reactions by which human
purine ribonucleotides and deoxyribonucleotides are degraded to uric acid in humans. Two …

The biosynthesis of purines and pyrimidines is stringently regulated and coordinated by
feedback mechanisms that ensure their production in quantities and at times appropriate to …

The disorders of purine and pyrimidine metabolism are unusual in their variety of clinical
presentations and in the mechanisms by which these presentations result from the …

A modelling approach is used to analyse diseases associated with purine metabolism in
man. The specific focus is on deficiencies in two enzymes, hypoxanthine: guanine …

Inborn errors of purine metabolism exhibit broad neurological, immunological,
haematological and renal manifestations. Limited awareness of the phenotypic spectrum …

The growing evidence of the involvement of purine compounds in signaling, of nucleotide
imbalance in tumorigenesis, the discovery of purinosome and its regulation, cast new light …

Purines perform many important functions in the cell, being the formation of the monomeric
precursors of nucleic acids DNA and RNA the most relevant one. Purines which also …

Purines, such as adenine and guanine, perform several important functions in the cell. They
are found in nucleic acids; are structural components of some coenzymes, including NADH …

Deamination of nucleobases in DNA and RNA results in the formation of xanthine (X),
hypoxanthine (I), oxanine, and uracil, all of which are miscoding and mutagenic in DNA and …

Purines are essential molecules that are components of vital biomolecules, such as nucleic
acids, coenzymes, signaling molecules, as well as energy transfer molecules. The de novo …