The study of marrow-resident mesodermal progenitors can provide important insight into
their role in influencing normal and aberrant hematopoiesis as occurs in acute myelogenous …

Acute myeloid leukemia (AML) is a bone marrow malignancy, and various bone marrow
stromal cells seem to support leukemogenesis, including osteoblasts and endothelial cells …

The bone marrow microenvironment may be permissive to the emergence and progression
of acute myeloid leukemia (AML). Studying interactions between the microenvironment and …

Abstract Background Mesenchymal stromal cells (MSCs) are an essential element of the
bone marrow (BM) microenvironment, playing a crucial function in regulating hematopoietic …

Myelodysplastic syndromes (MDS) are malignant hematopoietic stem cell disorders that
have the capacity to progress to acute myeloid leukemia (AML). Accumulating evidence …

Bone marrow mesenchymal stem/stromal cells (BM-MSCs) are key components of the
hematopoietic niche thought to have a direct role in leukemia pathogenesis. BM-MSCs from …

Mesenchymal stromal cells (MSCs) have, for a long time, been recognized as pivotal
contributors in the set up and maintenance of the hematopoietic stem cell (HSC) niche, as …

The importance of the bone marrow microenvironment forming the so‐called niche in
physiologic hemopoiesis is largely known, and recent evidences support the presence of …

Hematopoietic insufficiency is the hallmark of acute myeloid leukemia (AML) and
predisposes patients to life-threatening complications such as bleeding and infections …

Drug resistance in cancer, especially in leukemia, creates a dilemma in treatment planning.
Consequently, studies related to the mechanisms underlying drug resistance, the molecular …