RND pumps across the genus Acinetobacter: AdeIJK is the universal efflux pump
Acinetobacter are generally soil-dwelling organisms that can also cause serious human
infections. A. baumannii is one of the most common causative agents of Acinetobacter …
infections. A. baumannii is one of the most common causative agents of Acinetobacter …
Evolution of RND efflux pumps in the development of a successful pathogen
V Naidu, A Bartczak, AJ Brzoska, P Lewis… - Drug Resistance …, 2023 - Elsevier
Aims This study examined the origins and evolution of the AdeABC, AdeFGH and AdeIJK
efflux pumps in the Acinetobacter genus, including human and animal pathogens and …
efflux pumps in the Acinetobacter genus, including human and animal pathogens and …
Substrate specificities and efflux efficiencies of RND efflux pumps of Acinetobacter baumannii
Antibiotic-resistant Acinetobacter baumannii causes infections that are extremely difficult to
treat. A significant role in these resistance profiles is attributed to multidrug efflux pumps …
treat. A significant role in these resistance profiles is attributed to multidrug efflux pumps …
Properties of AdeABC and AdeIJK efflux systems of Acinetobacter baumannii compared with those of the AcrAB-TolC system of Escherichia coli
E Sugawara, H Nikaido - Antimicrobial agents and chemotherapy, 2014 - Am Soc Microbiol
Acinetobacter baumannii contains RND-family efflux systems AdeABC and AdeIJK, which
pump out a wide range of antimicrobial compounds, as judged from the MIC changes …
pump out a wide range of antimicrobial compounds, as judged from the MIC changes …
Prevalence of eight resistance-nodulation-division efflux pump genes in epidemiologically characterized Acinetobacter baumannii of worldwide origin
J Nowak, H Seifert, PG Higgins - Journal of medical …, 2015 - microbiologyresearch.org
The increasing emergence of multidrug-resistant Acinetobacter baumannii constitutes a
worldwide threat in hospital settings. Efflux-mediated resistance, particularly the resistance …
worldwide threat in hospital settings. Efflux-mediated resistance, particularly the resistance …
Efflux Pumps in Acinetobacter baumannii
T Schneiders, J Findlay, SGB Amyes - Acinetobacter Biology and …, 2008 - Springer
Acinetobacter baumannii has become a formidable nosocomial pathogen that has gained
prominence in the last decade. Its notoriety is largely attributed to the multidrug resistance …
prominence in the last decade. Its notoriety is largely attributed to the multidrug resistance …
Inactivation of AdeABC and AdeIJK efflux pumps elicits specific nonoverlapping transcriptional and phenotypic responses in Acinetobacter baumannii
Multidrug resistant (MDR) strains of Acinetobacter baumannii present a serious clinical
challenge. The development of antibiotic resistance in this species is enabled by efflux …
challenge. The development of antibiotic resistance in this species is enabled by efflux …
Efflux-Mediated Antibiotic Resistance in Acinetobacter spp
S Coyne, P Courvalin, B Périchon - Antimicrobial agents and …, 2011 - Am Soc Microbiol
Among Acinetobacter spp., A. baumannii is the most frequently implicated in nosocomial
infections, in particular in intensive care units. It was initially thought that multidrug …
infections, in particular in intensive care units. It was initially thought that multidrug …
AadT, a new weapon in Acinetobacter's fight against antibiotics
Genes encoding a novel multidrug efflux pump, AadT, from the Drug: H+ antiporter 2 family,
were discovered in Acinetobacter multidrug resistance plasmids. Here, we profiled the …
were discovered in Acinetobacter multidrug resistance plasmids. Here, we profiled the …
Acinetobacter nosocomialis: Defining the Role of Efflux Pumps in Resistance to Antimicrobial Therapy, Surface Motility, and Biofilm Formation
DB Knight, SD Rudin, RA Bonomo… - Frontiers in …, 2018 - frontiersin.org
Acinetobacter nosocomialis is a member of the Acinetobacter calcoaceticus-Acinetobacter
baumannii (ACB) complex. Increasingly, reports are emerging of the pathogenic profile and …
baumannii (ACB) complex. Increasingly, reports are emerging of the pathogenic profile and …