Diversity and origins of anaerobic metabolism in mitochondria and related organelles

CW Stairs, MM Leger, AJ Roger - … Transactions of the …, 2015 - royalsocietypublishing.org
Across the diversity of life, organisms have evolved different strategies to thrive in hypoxic
environments, and microbial eukaryotes (protists) are no exception. Protists that experience …

Reinventing an organelle: the reduced mitochondrion in parasitic protists

HJ Santos, T Makiuchi, T Nozaki - Trends in parasitology, 2018 - cell.com
Mitochondria originated from the endosymbiotic event commencing from the engulfment of
an ancestral α-proteobacterium by the first eukaryotic ancestor. Establishment of niches has …

[HTML][HTML] Highly divergent mitochondrion-related organelles in anaerobic parasitic protozoa

T Makiuchi, T Nozaki - Biochimie, 2014 - Elsevier
The mitochondria have arisen as a consequence of endosymbiosis of an ancestral α-
proteobacterium with a methane-producing archae. The main function of the canonical …

Organelles that illuminate the origins of Trichomonas hydrogenosomes and Giardia mitosomes

MM Leger, M Kolisko, R Kamikawa, CW Stairs… - Nature ecology & …, 2017 - nature.com
Many anaerobic microbial parasites possess highly modified mitochondria known as
mitochondrion-related organelles (MROs). The best-studied of these are the …

Diversity and reductive evolution of mitochondria among microbial eukaryotes

K Hjort, AV Goldberg, AD Tsaousis… - … of the Royal …, 2010 - royalsocietypublishing.org
All extant eukaryotes are now considered to possess mitochondria in one form or another.
Many parasites or anaerobic protists have highly reduced versions of mitochondria, which …

The earliest stages of mitochondrial adaptation to low oxygen revealed in a novel rhizarian

RMR Gawryluk, R Kamikawa, CW Stairs, JD Silberman… - Current Biology, 2016 - cell.com
Mitochondria exist on a functional and evolutionary continuum that includes anaerobic
mitochondrion-related organelles (MROs), such as hydrogenosomes. Hydrogenosomes lack …

Sawyeria marylandensis (Heterolobosea) has a hydrogenosome with novel metabolic properties

MJ Barbera, I Ruiz-Trillo, JYA Tufts, A Bery… - Eukaryotic …, 2010 - Am Soc Microbiol
Protists that live under low-oxygen conditions often lack conventional mitochondria and
instead possess mitochondrion-related organelles (MROs) with distinct biochemical …

Intermediary metabolism in protists: a sequence-based view of facultative anaerobic metabolism in evolutionarily diverse eukaryotes

ML Ginger, LK Fritz-Laylin, C Fulton, WZ Cande… - Protist, 2010 - Elsevier
Protists account for the bulk of eukaryotic diversity. Through studies of gene and especially
genome sequences the molecular basis for this diversity can be determined. Evident from …

Mitochondrion-related organelles in eukaryotic protists

AM Shiflett, PJ Johnson - Annual review of microbiology, 2010 - annualreviews.org
The discovery of mitochondrion-type genes in organisms thought to lack mitochondria led to
the demonstration that hydrogenosomes share a common ancestry with mitochondria, as …

Diversity in mitochondrial metabolic pathways in parasitic protists Plasmodium and Cryptosporidium

T Mogi, K Kita - Parasitology International, 2010 - Elsevier
Apicomplexans are obligate intracellular parasites and occupy diverse niches. They have
remodeled mitochondrial carbon and energy metabolism through reductive evolution …