[PDF][PDF] Celocoxib inhibits osteoblast maturation by suppressing the expression of Wnt target genes

A Nagano, M Arioka, F Takahashi-Yanaga… - J Pharmacol …, 2016 - cyberleninka.org
abstract Non-steroidal anti-inflammatory drugs (NSAIDs) have been shown to impair bone
healing. We previously reported that in colon cancer cells, celecoxib, a COX-2-selective …

[HTML][HTML] Celecoxib inhibits osteoblast maturation by suppressing the expression of Wnt target genes

A Nagano, M Arioka, F Takahashi-Yanaga… - Journal of …, 2017 - Elsevier
Non-steroidal anti-inflammatory drugs (NSAIDs) have been shown to impair bone healing.
We previously reported that in colon cancer cells, celecoxib, a COX-2-selective NSAID …

Celecoxib inhibits osteoblast maturation by suppressing the expression of the Wnt target genes

永野晃弘 - 2013 - catalog.lib.kyushu-u.ac.jp
概要 非ステロイド性抗炎症薬 (NSAIDs) は骨折の治癒を阻害することが知られている. 我々は,
cyclooxygenase-2 選択的 NSAIDs であるセレコキシブが, 骨芽細胞においてその分化に重要な …

Celecoxib inhibits osteoblast differentiation independent of cyclooxygenase activity

A Matsuyama, S Higashi, S Tanizaki… - Clinical and …, 2018 - Wiley Online Library
Non‐steroidal anti‐inflammatory drugs (NSAID s) exert their effects primarily by inhibiting the
activity of cyclooxygenase (COX), thus suppressing prostaglandin synthesis. Some NSAID s …

[HTML][HTML] Effects of therapeutic doses of celecoxib on several physiological parameters of cultured human osteoblasts

VJ Costela-Ruiz, L Melguizo-Rodríguez… - … Journal of Medical …, 2019 - ncbi.nlm.nih.gov
Non-steroidal anti-inflammatory drugs (NSAIDs), including cyclooxygenase-2 (COX-2)-
selective NSAIDs, are associated with adverse effects on bone tissue. These drugs are …

[HTML][HTML] EFFECTS OF STEROID, NONSTEROIDAL ANTI-INFLAMMATORY DRUGS, AND COX-2 SELECTIVE INHIBITORS ON PROLIFERATION AND …

ML Ho, JK Chang, CJ Li, GJ Wang - Orthopaedic Proceedings, 2004 - boneandjoint.org.uk
Introduction: Nonsteroidal anti-inflammatory drugs (NSAIDs) have been reported to
suppress bone repair and remodeling in vivo. Our previous studies showed that NSAIDs …

The selective cyclooxygenase-2 inhibitor celecoxib reduces bone resorption, but not bone formation, in ovariectomized mice in vivo

Y Kasukawa, N Miyakoshi, AK Srivastava… - The Tohoku journal of …, 2007 - jstage.jst.go.jp
Exp. Med. 2007, 211 (3), 275-283── Suppression of increased bone resorption is an
important issue in treatment of post-menopausal osteoporosis. Celecoxib is a highly …

[HTML][HTML] Repercussion of nonsteroidal anti-inflammatory drugs on the gene expression of human osteoblasts

L Melguizo-Rodríguez, VJ Costela-Ruiz… - PeerJ, 2018 - peerj.com
Background Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently used in clinical
practice, which can have adverse effects on the osteoblast. The objective of this study was to …

Cell Model System for Glucocorticoid-Induced Osteoporosis

F Halla, E Jennings, J Oxford, S Tuft, A Fujimoto - 2020 - scholarworks.boisestate.edu
Dexamethasone, a corticosteroid that inhibits inflammation, is commonly used for the
treatment of arthritis. However, glucocorticoid-induced osteoporosis is a side effect that …

Cyclooxygenase-2 inhibitor rofecoxib prevents chondrocytes against hypertrophy via Wnt/β-catenin pathway.

YR Yang, XF Yang, HC Duan… - Journal of Biological …, 2020 - europepmc.org
Previous reports indicated that specific cyclooxygenase-2 (COX-2) inhibitor suppresses
osteoarthritis (OA). This study aimed to further explore the possible mechanism of Rofecoxib …