Glycine transporters are endogenous regulators of the dual functions of glycine, which acts
as a classical inhibitory neurotransmitter at glycinergic synapses and as a modulator of …

In the forebrain, synaptic glycine concentrations are regulated through the glycine
transporter GlyT1. Because glycine is a coagonist of the N-methyl-d-aspartate (NMDA) …

In the central nervous system, glutamate is essential for a proper synaptic communication in
neuronal networks supporting critical behavioral activities such as learning and memory …

Glycine has important neurotransmitter functions at inhibitory and excitatory synapses in the
vertebrate central nervous system. The effective synaptic concentrations of glycine are …

Abstract Glycine transporters (GlyTs) are Na+/Cl−-dependent neurotransmitter transporters,
responsible for l-glycine uptake into the central nervous system. GlyTs are members of the …

The functions of the high-affinity glycine transporters (GLYTs) in vivo have been revealed
recently using gene-deletion studies. Results from studies of homozygous knockout mice …

The ionotropic glutamate receptor NMDA is allosterically modulated by glycine, a coagonist,
its presence is an absolute requirement for receptor activation. The transport of glycine in …

A growing body of evidence suggests that activation of the glutamatergic system, particularly
N-methyl-d-aspartate (NMDA) receptor function, may be a viable approach to the treatment …

Current antipsychotic drugs are only partially effective in treating schizophrenia and there is
a clear need to develop better therapies. An alternative approach to develop new …

Clinically utilized antipsychotic agents share as a common mechanism the ability to
antagonize dopamine D2 receptors and it is widely assumed that this activity contributes to …