Pituitary gonadotropins directly govern ovarian functions, which are in turn regulated by the
ovarian steroid hormones. The precise interplay of gonadotropins and steroid hormones is …

Excess calorie consumption, particularly of a diet high in fat, is a risk factor for both obesity
and reproductive disorders. Animal model studies indicate that elevated dietary fat can …

Objective To examine the effects of high-fat (HF) diet–induced maternal obesity on follicular
population and gene expression in adult offspring ovaries. Design Experimental mouse …

The regulatory mechanism of granulosa cells (GCs) proliferation during the follicular
development is complicated and multifactorial, which is essential for the oocyte growth and …

Autophagy is an essential cellular mechanism that degrades cytoplasmic proteins and
organelles to recycle their components. Here we showed that autophagy was essential for …

STUDY QUESTION Does hypo-glycosylated human recombinant FSH (hFSH18/21) have
greater in vivo bioactivity that drives follicle development in vivo compared to fully …

Little is known about the molecular relationships among follicle stimulating hormone (FSH),
lipid droplet (LD) degradation, and autophagy. In this study, we aimed to investigate the …

Context Excessive consumption of high-fat diets has increased in the population over time
and is harmful to female fertility. Objective To investigate and discuss the effects of a high-fat …

In a growing follicle, the survival and maturation of the oocyte largely depend on support
from somatic cells to facilitate FSH-induced mutual signaling and chemical communication …

We have previously shown that follicle-stimulating hormone receptor haploinsufficient mice
undergo early reproductive senescence with alterations in ovarian structures. The objective …