Bacterial Lipopolysaccharide Induces an Endocrine Switch from Prostaglandin F to Prostaglandin E2 in Bovine Endometrium

S Herath, ST Lilly, DP Fischer, EJ Williams… - …, 2009 - academic.oup.com
Escherichia coli infection of the endometrium causes uterine disease after parturition and is
associated with prolonged luteal phases of the ovarian cycle in cattle. Termination of the …

Effect of Escherichia coli infection of the bovine uterus from the whole animal to the cell

EJ Williams, S Herath, GCW England, H Dobson… - Animal, 2008 - Elsevier
Following parturition, contamination of the uterine lumen by bacteria is ubiquitous, and
uterine health is impaired in cattle because infection persists in 10% to 15% of animals as …

[HTML][HTML] Distinct phospholipase A2 enzymes regulate prostaglandin E2 and F2alpha production by bovine endometrial epithelial cells

PK Tithof, MP Roberts, W Guan, M Elgayyar… - Reproductive Biology …, 2007 - Springer
Background The rate-limiting step in prostaglandin (PG) biosynthesis is catalyzed by
phospholipase A2 (PLA2) enzymes which hydrolyze arachidonic acid from membrane …

[HTML][HTML] Toll-like receptor and antimicrobial peptide expression in the bovine endometrium

D Davies, KG Meade, S Herath, PD Eckersall… - Reproductive Biology …, 2008 - Springer
Background The endometrium is commonly infected with bacteria leading to severe disease
of the uterus in cattle and humans. The endometrial epithelium is the first line of defence for …

Time course of defense mechanisms in bovine endometrium in response to lipopolysaccharide

T Swangchan-Uthai, CRM Lavender… - Biology of …, 2012 - academic.oup.com
Endometritis caused by uterine infection after calving reduces fertility and causes major
economic losses to the dairy industry. This study investigated the time course of an …

Expression and function of Toll-like receptor 4 in the endometrial cells of the uterus

S Herath, DP Fischer, D Werling, EJ Williams… - …, 2006 - academic.oup.com
Prostaglandins have a central role in many endocrine functions in mammals, including
regulation of the life span of the corpus luteum by prostaglandin F2α (PGF) and …

The effects of lipopolysaccharide and interleukins-1alpha,-2 and-6 on oxytocin receptor expression and prostaglandin production in bovine endometrium

ST Leung, Z Cheng, EL Sheldrick… - Journal of …, 2001 - joe.bioscientifica.com
Up-regulation of endometrial oxytocin receptor (OTR) expression followed by an increase in
pulsatile endometrial prostaglandin (PG) F (2alpha) secretion causes luteolysis in cattle …

[HTML][HTML] Steroidal regulation of uterine resistance to bacterial infection in livestock

GS Lewis - Reproductive biology and endocrinology, 2003 - Springer
Postpartum uterine infections reduce reproductive efficiency and have significant animal
welfare and economic consequences. Postpartum uterine infections are classified as …

Endometrial expression of selected transcripts involved in prostaglandin synthesis in cows with endometritis

C Gabler, M Drillich, C Fischer, C Holder, W Heuwieser… - Theriogenology, 2009 - Elsevier
Several cytokines and prostaglandins play an important role in preparing the endometrium
for implantation and mediating pro-inflammatory events. The aim of the present study was to …

The Effect of Escherichia coli Lipopolysaccharide and Tumour Necrosis Factor Alpha on Ovarian Function

EJ Williams, K Sibley, AN Miller… - American journal of …, 2008 - Wiley Online Library
Problem Pelvic inflammatory disease and metritis are important causes of infertility in
humans and domestic animals. Uterine infection with Escherichia coli in cattle is associated …